Papyrus 21
| New Testament manuscript | |
| Page recto with text of Matthew 12:24-26 | |
| Name | P. Oxy. 1227 | 
|---|---|
| Text | Matthew 12:24-33 † | 
| Date | 4th century | 
| Script | Greek | 
| Found | Egypt | 
| Now at | Muhlenberg College | 
| Cite | B. P. Grenfell & A. S. Hunt, Oxyrynchus Papyri X, pp. 12-14 | 
| Size | 11.5 cm by 4.5 cm | 
| Type | mixed | 
| Category | III | 
Papyrus 21 (in the Gregory-Aland numbering), designated by siglum 𝔓21, is an early copy of the New Testament in Greek. It is a papyrus manuscript of the Gospel of Matthew, it contains only Matthew 12:24-26.32-33. The manuscript paleographically had been assigned to the early 4th century.