Parabiosis

Parabiosis is a laboratory technique used in physiological research, derived from the Greek word meaning "living beside." The technique involves the surgical joining of two living organisms in such a way that they develop a single, shared physiological system. Through this approach, researchers can study the exchange of blood, hormones, and other substances between the two organisms, allowing for the examination of a wide range of physiological phenomena and interactions. Parabiosis has been employed in various fields of study, including stem cell research, endocrinology, aging research, and immunology.

Heterochronic parabiosis involves parabiosis of animals of different ages; this allows researchers to study how circulating blood-borne factors influence aging and tissue regeneration. The method has led to insights into stem cell function, neurogenesis, regeneration (biology), and aging. In contrast, isochronic parabiosis joins two animals of the same age.

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