Parathyroid hormone receptor
| parathyroid hormone 1 receptor | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | PTH1R | ||||||
| Alt. symbols | PTHR, PFE | ||||||
| NCBI gene | 5745 | ||||||
| HGNC | 9608 | ||||||
| OMIM | 168468 | ||||||
| RefSeq | NM_000316 | ||||||
| UniProt | Q03431 | ||||||
| Other data | |||||||
| Locus | Chr. 3 p22-p21.1 | ||||||
| |||||||
| parathyroid hormone 2 receptor | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | PTH2R | ||||||
| NCBI gene | 5746 | ||||||
| HGNC | 9609 | ||||||
| OMIM | 601469 | ||||||
| RefSeq | NM_005048 | ||||||
| UniProt | P49190 | ||||||
| Other data | |||||||
| Locus | Chr. 2 q33 | ||||||
| |||||||
There are two known parathyroid hormone receptors in mammals termed PTH1R and PTH2R. These receptors bind parathyroid hormone and are members of the GPCR family of transmembrane proteins.
- parathyroid hormone 1 receptor (PTH1R) is the classical PTH receptor, is expressed in high levels in bone and kidney and regulates calcium ion homeostasis through activation of adenylate cyclase and phospholipase C.
- parathyroid hormone 2 receptor (PTH2R) is expressed primarily in the central nervous system, pancreas, testis, and placenta.