Pentagastrin

Pentagastrin
Clinical data
AHFS/Drugs.com	Micromedex Detailed Consumer Information
ATC code	V04CG04 (WHO) ;
Pharmacokinetic data
Elimination half-life	10 minutes or less
Identifiers
	IUPAC name N-(tert-butoxycarbonyl)-β-alanyl-L-tryptophyl-L-methionyl-L-α-aspartyl-L-phenylalaninamide;
CAS Number	5534-95-2 ;
PubChem CID	9853654;
IUPHAR/BPS	870;
DrugBank	DB00183 ;
ChemSpider	8029364 ;
UNII	EF0NX91490;
KEGG	D01631 ;
ChEMBL	ChEMBL1328 ;
CompTox Dashboard (EPA)	DTXSID3048992 ;
ECHA InfoCard	100.024.445
Chemical and physical data
Formula	C37H49N7O9S
Molar mass	767.90 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(N)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CCNC(=O)OC(C)(C)C)Cc2c1ccccc1[nH]c2)CCSC)CC(=O)O)Cc3ccccc3;
	InChI InChI=1S/C37H49N7O9S/c1-37(2,3)53-36(52)39-16-14-30(45)41-28(19-23-21-40-25-13-9-8-12-24(23)25)34(50)42-26(15-17-54-4)33(49)44-29(20-31(46)47)35(51)43-27(32(38)48)18-22-10-6-5-7-11-22/h5-13,21,26-29,40H,14-20H2,1-4H3,(H2,38,48)(H,39,52)(H,41,45)(H,42,50)(H,43,51)(H,44,49)(H,46,47)/t26-,27-,28-,29-/m0/s1 ; Key:NEYNJQRKHLUJRU-DZUOILHNSA-N ;
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Pentagastrin (trade name Peptavlon) is a synthetic polypeptide that has effects like gastrin when given parenterally. It stimulates the secretion of gastric acid, pepsin, and intrinsic factor, and has been used as a diagnostic aid as the pentagastrin-stimulated calcitonin test.

Pentagastrin binds to the cholecystokinin-B receptor, which is expressed widely in the brain. Activation of these receptors activates the phospholipase C second messenger system. When given intravenously it may cause panic attacks.

Pentagastrin's IUPAC chemical name is "N-((1,1-dimethylethoxy)carbonyl)-beta-alanyl-L-tryptophyl-L-methionyl-L-alpha-aspartyl-L-phenylalaninamide".