Peptide YY

PYY
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2L60, 2DEZ, 2DF0
Identifiers
Aliases	PYY, PYY-I, PYY1, peptide YY
External IDs	OMIM: 600781; MGI: 99924; HomoloGene: 3066; GeneCards: PYY; OMA:PYY - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	44,004,469 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	101,998,658 bp
RNA expression pattern
	Top expressed in
	mucosa of sigmoid colon; ; mucosa of transverse colon; ; rectum; ; testicle; ; gonad; ; mucosa of ileum; ; epithelium of colon; ; jejunal mucosa; ; duodenum; ; appendix;
	Top expressed in
	islet of Langerhans; ; left colon; ; ileum; ; intestinal villus; ; embryo; ; blastocyst; ; embryo; ; jejunum; ; crypt of lieberkuhn of small intestine; ; duodenum;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; hormone activity; neuropeptide hormone activity; G protein-coupled receptor binding;
Cellular component	extracellular region; extracellular space;
Biological process	G protein-coupled receptor signaling pathway; regulation of appetite; cell population proliferation; neuropeptide signaling pathway; feeding behavior; regulation of signaling receptor activity; intestinal epithelial cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
	5697
	217212
	ENSG00000131096
	ENSMUSG00000017311
	P10082
	Q9EPS2
	NM_004160; NM_001394028; NM_001394029
	NM_145435; NM_001346771
	NP_004151
	NP_001333700; NP_663410
	Wikidata
View/Edit Human	View/Edit Mouse

Peptide YY (PYY), also known as peptide tyrosine tyrosine, is a peptide that in humans is encoded by the PYY gene. Peptide YY is a short (36-amino acid) peptide released from cells in the ileum and colon in response to feeding. In the blood, gut, and other elements of periphery, PYY acts to reduce appetite; similarly, when injected directly into the central nervous system, PYY is also anorexigenic, i.e., it reduces appetite.

Dietary fibers from fruits, vegetables, and whole grains, consumed, increase the speed of transit of intestinal chyme into the ileum, to raise PYY_3-36, and induce satiety. Peptide YY cannot be produced as the result of enzymatic breakdown of crude fish proteins and ingested as a food product.