Perforin-1

PRF1
Identifiers
Aliases	PRF1, FLH2, HPLH2, P1, PFN1, PFP, perforin 1
External IDs	OMIM: 170280; MGI: 97551; HomoloGene: 3698; GeneCards: PRF1; OMA:PRF1 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	70,602,759 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	61,140,459 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; blood; ; spleen; ; decidua; ; bone marrow cells; ; buccal mucosa cell; ; apex of heart; ; lymph node; ; superficial temporal artery; ; upper lobe of left lung;
	Top expressed in
	gastrula; ; decidua; ; blood; ; lumbar subsegment of spinal cord; ; embryo; ; spleen; ; lymph node; ; subcutaneous adipose tissue; ; thymus; ; right lung;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; metal ion binding; calcium ion binding; wide pore channel activity; identical protein binding;
Cellular component	integral component of membrane; extracellular region; endosome; plasma membrane; endosome lumen; membrane; cytosol; cytoplasmic vesicle; cytolytic granule;
Biological process	cellular defense response; immunological synapse formation; cytolysis; apoptotic process; transmembrane transport; positive regulation of killing of cells of other organism; defense response to tumor cell; immune response to tumor cell; protein homooligomerization; defense response to virus; T cell mediated cytotoxicity;
	Sources:Amigo / QuickGO
Orthologs
	5551
	18646
	ENSG00000180644
	ENSMUSG00000037202
	P14222
	P10820
	NM_005041; NM_001083116
	NM_011073
	NP_001076585; NP_005032
	NP_035203
	Wikidata
View/Edit Human	View/Edit Mouse

Perforin-1 Perforin (PRF), encoded by the PRF1 gene, is a pore-forming toxic protein housed in the secretory granules of cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells. Together, these cells are known as cytotoxic lymphocytes (CLs).