Perindopril

Perindopril
	Above: molecular structure of perindopril Below: 3D representation of a perindopril molecule
Clinical data
Trade names	Coversyl, Coversum, Aceon
AHFS/Drugs.com	Perindopril Monograph
MedlinePlus	Perindopril
License data	US DailyMed: Perindopril;
Routes of; administration	By mouth
ATC code	C09AA04 (WHO) ; C09BA04 (WHO) (with diuretics); C09BB04 (WHO) (with amlodipine);
Legal status
Legal status	CA: ℞-only; UK: POM (Prescription only); US: ℞-only;
Pharmacokinetic data
Bioavailability	24%
Protein binding	20%
Metabolism	Kidney
Elimination half-life	1–17 hours for perindoprilat (active metabolite)
Identifiers
	IUPAC name (2S,3aS,7aS)-1-[(2S)-2-{[(2S)-1-ethoxy-1-oxopentan-2-yl]amino}propanoyl]-octahydro-1H-indole-2-carboxylic acid;
CAS Number	82834-16-0 ;
PubChem CID	107807;
IUPHAR/BPS	6367;
DrugBank	DB00790 ;
ChemSpider	96956 ;
UNII	Y5GMK36KGY;
KEGG	D03753 ;
ChEBI	CHEBI:8024 ;
ChEMBL	ChEMBL1581 ;
CompTox Dashboard (EPA)	DTXSID6023440 ;
ECHA InfoCard	100.120.843
Chemical and physical data
Formula	C19H32N2O5
Molar mass	368.474 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(OCC)[C@@H](N[C@H](C(=O)N1[C@H](C(=O)O)C[C@@H]2CCCC[C@H]12)C)CCC;
	InChI InChI=1S/C19H32N2O5/c1-4-8-14(19(25)26-5-2)20-12(3)17(22)21-15-10-7-6-9-13(15)11-16(21)18(23)24/h12-16,20H,4-11H2,1-3H3,(H,23,24)/t12-,13-,14-,15-,16-/m0/s1 ; Key:IPVQLZZIHOAWMC-QXKUPLGCSA-N ;
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Perindopril is a medication used to treat high blood pressure, heart failure, or stable coronary artery disease.

As a long-acting ACE inhibitor, perindopril works by inhibiting production of the vasoconstriction hormone, angiotensin, thereby relaxing blood vessels, increasing urine output, and decreasing blood volume, leading to a reduction of blood pressure. It also increases blood renin activity and decreases aldosterone secretion, causing increased urine production and excretion of sodium.

As a prodrug, perindopril is hydrolyzed in the liver to its active metabolite, perindoprilat. It was patented in 1980 and approved for medical use in 1988.

Perindopril is taken in the form of perindopril arginine/amlodipine or perindopril erbumine. Both forms are therapeutically equivalent and interchangeable, but the dose prescribed to achieve the same effect may differ between the two forms.

Perindopril should not be used during pregnancy, as it may harm the fetus. Some people may have allergic reactions to perindopril, while common side-effects may include cough, headache, dizziness, diarrhea, or upset stomach.

In Australia during 2023-24, it was the fourth-most prescribed drug.