Phosphopentose epimerase
| ribulose-phosphate 3-epimerase | |||||||||
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D-ribulose-5-phosphate 3-epimerase dodekamer, Francisella tularensis | |||||||||
| Identifiers | |||||||||
| EC no. | 5.1.3.1 | ||||||||
| CAS no. | 9024-20-8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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| Ribulose-phosphate 3 epimerase family | |||||||||||
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| Identifiers | |||||||||||
| Symbol | Ribul_P_3_epim | ||||||||||
| Pfam | PF00834 | ||||||||||
| InterPro | IPR000056 | ||||||||||
| PROSITE | PDOC00833 | ||||||||||
| SCOP2 | 1rpx / SCOPe / SUPFAM | ||||||||||
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Phosphopentose epimerase (also known as ribulose-phosphate 3-epimerase and ribulose 5-phosphate 3-epimerase, EC 5.1.3.1) encoded in humans by the RPE gene is a metalloprotein that catalyzes the interconversion between D-ribulose 5-phosphate and D-xylulose 5-phosphate.
- D-ribulose 5-phosphate D-xylulose 5-phosphate
This reversible conversion is required for carbon fixation in plants – through the Calvin cycle – and for the nonoxidative phase of the pentose phosphate pathway. This enzyme has also been implicated in additional pentose and glucuronate interconversions.
In Cupriavidus metallidurans two copies of the gene coding for PPE are known, one is chromosomally encoded P40117, the other one is on a plasmid Q04539. PPE has been found in a wide range of bacteria, archaebacteria, fungi and plants. All the proteins have from 209 to 241 amino acid residues. The enzyme has a TIM barrel structure.