Piperazine
| Names | |
|---|---|
| Preferred IUPAC name
Piperazine | |
| Systematic IUPAC name
1,4-Diazacyclohexane | |
| Other names
Hexahydropyrazine Piperazidine Diethylenediamine 1,4-Diazinane | |
| Identifiers | |
3D model (JSmol) |
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| ChEBI | |
| ChEMBL | |
| ChemSpider | |
| DrugBank | |
| ECHA InfoCard | 100.003.463 |
| KEGG | |
PubChem CID |
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| UNII | |
CompTox Dashboard (EPA) |
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| Properties | |
| C4H10N2 | |
| Molar mass | 86.138 g·mol−1 |
| Appearance | White crystalline solid |
| Melting point | 106 °C (223 °F; 379 K) |
| Boiling point | 146 °C (295 °F; 419 K) Sublimes |
| Freely soluble | |
| Acidity (pKa) | 9.8 |
| Basicity (pKb) | 4.19 |
| −56.8·10−6 cm3/mol | |
| Pharmacology | |
| P02CB01 (WHO) | |
| Pharmacokinetics: | |
| 60-70% | |
| Hazards | |
| NFPA 704 (fire diamond) | |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references | |
Piperazine (/paɪˈpɛrəziːn/) is an organic compound with the formula (CH2CH2NH)2. In term of its structure, it can be described as cyclohexane with the 1- and 4-CH2 groups replaced by NH. Piperazine exists as deliquescent solid with a saline taste. Piperazine is freely soluble in water and ethylene glycol, but poorly soluble in diethyl ether. Piperazine is commonly available industrially is as the hexahydrate, (CH2CH2NH)2·6H2O, which melts at 44 °C and boils at 125–130 °C.
Substituted derivatives of piperazine are a broad class of chemical compounds. Many piperazines have useful pharmacological properties, prominent examples include viagra, ciprofloxacin, and ziprasidone.