Pleckstrin homology domain
PH domain of tyrosine-protein kinase BTK | |||||||||
| Identifiers | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Symbol | PH | ||||||||
| Pfam | PF00169 | ||||||||
| Pfam clan | CL0266 | ||||||||
| ECOD | 220.1.1 | ||||||||
| InterPro | IPR001849 | ||||||||
| SMART | PH | ||||||||
| PROSITE | PDOC50003 | ||||||||
| SCOP2 | 1dyn / SCOPe / SUPFAM | ||||||||
| OPM superfamily | 49 | ||||||||
| OPM protein | 1pls | ||||||||
| CDD | cd00821 | ||||||||
| |||||||||
Pleckstrin homology domain (PH domain) or (PHIP) is a protein domain of approximately 120 amino acids that occurs in a wide range of proteins involved in intracellular signaling or as constituents of the cytoskeleton.
This domain can bind phosphatidylinositol lipids within biological membranes (such as phosphatidylinositol (3,4,5)-trisphosphate and phosphatidylinositol (4,5)-bisphosphate), and proteins such as the βγ-subunits of heterotrimeric G proteins, and protein kinase C. Through these interactions, PH domains play a role in recruiting proteins to different membranes, thus targeting them to appropriate cellular compartments or enabling them to interact with other components of the signal transduction pathways.