Poppers

Poppers
A selection of over-the-counter poppers on display
Clinical data
Other namespopper, poppe, pops
Routes of
administration
Inhalation
Drug classVasodilator
Legal status
Legal status
  • AU: S4 (Prescription only) in general; some exceptions
  • Elsewhere, usually available OTC
Pharmacokinetic data
BioavailabilityWhen inhaled,
  • Amyl nitrite: unknown
  • Isopropyl nitrite: 43%
  • Isobutyl nitrite: unknown
MetabolismLiver
Metabolites
Onset of action15 seconds
Elimination half-lifeSuspected to be minutes to less than an hour
Duration of action30 seconds to 5 minutes
ExcretionPrimarily urine
Chemical and physical data
Formula Depends on primary active ingredient
Molar mass Depends on primary active ingredient
Boiling pointDepends on primary active ingredient

Poppers are recreational drugs belonging to the alkyl nitrite family of chemical compounds. When fumes from these substances are inhaled, they act as potent vasodilators, producing mild euphoria, warmth, and dizziness. Most effects have a rapid onset and are short-acting. Its recreational use is believed to be potentially dangerous for people with heart problems, anaemia, or glaucoma. Reported adverse effects include fainting, retinal toxicity, and vision loss.

As poppers include a broad range of chemical types, their legality differs across different jurisdictions. They are often packaged under the guise of room deodorizer, leather polish, nail polish remover, or videotape head cleaner to evade anti-drug laws.

The term poppers comes from the popping sound made when glass vials of the substance were crushed to release the vapors for inhalation. Amyl nitrite was originally prescribed in the late 1800s for the medical management of angina. Many analogues exist, such as isoamyl nitrite, isopentyl nitrite, isopropyl nitrite, and isobutyl nitrite. These substances are subject to different regulations; for example, isobutyl nitrite is banned in the European Union.

Poppers act as muscle relaxants, causing the relaxation of involuntary smooth muscles such as the throat and anus. Such physiological effects, along with others (such as mild euphoria), have resulted in poppers being used as recreational drugs, sometimes during sexual intercourse, as the effects can heighten arousal and help facilitate acts such as anal intercourse. Poppers were a part of the club culture which began during the mid-1970s disco scene, and surged in popularity during the rave scene of the 1980s and 1990s.