Portrait of Margaret van Eyck

Portrait of Margaret van Eyck (or Margaret, the Artist's Wife) is a 1439 oil on wood painting by the Early Netherlandish painter Jan van Eyck. It is one of the latest of his surviving paintings, and one of the earliest European artworks to depict a painter's spouse. The painting was made when she was around 34, and was hung until the early 18th century in the Bruges Chapel of the Guild of Painters. It is today in the Groeningemuseum in Bruges, Belgium.

Art historians believe it was once a pendant (diptych) panel for Jan's likely self-portrait in the National Gallery, London. The panel was in poor condition with cracks on the painted surface coupled with accumulated dirt causing discolour, until is was cleaned and restored in 1998 during it's loan to the National Gallery, when it also received extensive technical examination.