Prajmaline

Prajmaline
Clinical data
ATC code	C01BA08 (WHO) ;
Identifiers
	IUPAC name (4α,16R,17R,21α)-4-propylajmalan-4-ium-17,21-diol;
CAS Number	35080-11-6 ;
PubChem CID	37042;
ChemSpider	16735977 ;
UNII	75934UD4GJ;
CompTox Dashboard (EPA)	DTXSID6023494 ;
Chemical and physical data
Formula	C23H33N2O2+
Molar mass	369.529 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O[C@@H]6C4[C@@H]2C[C@]65c1ccccc1N(C)[C@H]5[C@@H]3C[C@H]4[C@H](CC)[C@@H](O)[N+]23CCC;
	InChI InChI=1S/C23H33N2O2/c1-4-10-25-17-11-14(13(5-2)22(25)27)19-18(25)12-23(21(19)26)15-8-6-7-9-16(15)24(3)20(17)23/h6-9,13-14,17-22,26-27H,4-5,10-12H2,1-3H3/q+1/t13-,14-,17-,18-,19?,20-,21+,22+,23+,25?/m0/s1 ; Key:UAUHEPXILIZYCU-UUEXUKNBSA-N ;
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Prajmaline (Neo-gilurythmal) is a class Ia antiarrhythmic agent which has been available since the 1970s. Class Ia drugs increase the time one action potential lasts in the heart. Prajmaline is a semi-synthetic propyl derivative of ajmaline, with a higher bioavailability than its predecessor. It acts to stop arrhythmias of the heart through a frequency-dependent block of cardiac sodium channels.

Clinical data

ATC code	C01BA08 (WHO)
Identifiers
IUPAC name (4α,16R,17R,21α)-4-propylajmalan-4-ium-17,21-diol
CAS Number	35080-11-6^N
PubChem CID	37042
ChemSpider	16735977^Y
UNII	75934UD4GJ
CompTox Dashboard (EPA)	DTXSID6023494
Chemical and physical data
Formula	C₂₃H₃₃N₂O₂⁺
Molar mass	369.529 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES O[C@@H]6C4[C@@H]2C[C@]65c1ccccc1N(C)[C@H]5[C@@H]3C[C@H]4[C@H](CC)[C@@H](O)[N+]23CCC
InChI InChI=1S/C23H33N2O2/c1-4-10-25-17-11-14(13(5-2)22(25)27)19-18(25)12-23(21(19)26)15-8-6-7-9-16(15)24(3)20(17)23/h6-9,13-14,17-22,26-27H,4-5,10-12H2,1-3H3/q+1/t13-,14-,17-,18-,19?,20-,21+,22+,23+,25?/m0/s1^Y Key:UAUHEPXILIZYCU-UUEXUKNBSA-N^Y
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