Prefoldin
| Prefoldin | |
|---|---|
This is the crystal structure of an archaeal prefoldin taken from the archaeon Methanobacterium thermoautotrophicum. The image was produced by Siegerts, R., Scheufler, C., Moarefi, I. using X-Ray diffraction. The heterohexameric protein complex contains two alpha subunits, and four beta subunits.
(PDB: 1FXK) | |
| Identifiers | |
| Symbol | Prefoldin |
| InterPro | IPR009053 |
| CATH | 1fxk |
| SCOP2 | 1fxk / SCOPe / SUPFAM |
Prefoldin (GimC) is a superfamily of proteins used in protein folding complexes. It is classified as a heterohexameric molecular chaperone in both archaea and eukarya, including humans. A prefoldin molecule works as a transfer protein in conjunction with a molecule of chaperonin to form a chaperone complex and correctly fold other nascent proteins. One of prefoldin's main uses in eukarya is the formation of molecules of actin for use in the eukaryotic cytoskeleton.