Primary mediastinal B-cell lymphoma

Primary mediastinal large B-cell lymphoma
Micrograph of a primary mediastinal large B-cell lymphoma. H&E stain.
SpecialtyHematology and oncology

Primary mediastinal B-cell lymphoma, abbreviated PMBL or PMBCL, is a rare type of lymphoma that forms in the mediastinum (the space in between the lungs) and predominantly affects young adults.

While it had previously been considered a subtype of diffuse large B-cell lymphoma;, the World Health Organization no longer classifies it as such, based on distinct clinicopathologic and molecular features.

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