Prohibitin

PHB1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1LU7
Identifiers
Aliases	PHB1, prohibitin, HEL-S-54e, HEL-215, PHB, prohibitin 1
External IDs	OMIM: 176705; MGI: 97572; HomoloGene: 1980; GeneCards: PHB1; OMA:PHB1 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	49,414,905 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	95,571,599 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; rectum; ; islet of Langerhans; ; right auricle of heart; ; apex of heart; ; minor salivary glands; ; muscle of thigh; ; right adrenal gland; ; left ventricle; ; left adrenal gland;
	Top expressed in
	yolk sac; ; right kidney; ; muscle of thigh; ; embryo; ; embryo; ; dentate gyrus of hippocampal formation granule cell; ; neural layer of retina; ; proximal tubule; ; ventricular zone; ; internal carotid artery;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	histone deacetylase binding; complement component C3a binding; protein C-terminus binding; proteinase activated receptor binding; complement component C3b binding; protein binding; enzyme binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; membrane; myelin sheath; plasma membrane; integral component of plasma membrane; nucleoplasm; cell surface; early endosome; mitochondrion; mitochondrial inner membrane; extracellular exosome; nucleus; postsynaptic density; mitochondrial crista; extrinsic component of mitochondrial outer membrane; extrinsic component of presynaptic active zone membrane; glutamatergic synapse; GABA-ergic synapse;
Biological process	regulation of apoptotic process; negative regulation of glucocorticoid receptor signaling pathway; DNA biosynthetic process; regulation of transcription, DNA-templated; cellular response to interleukin-6; negative regulation of protein catabolic process; negative regulation of transcription by competitive promoter binding; protein stabilization; negative regulation of androgen receptor signaling pathway; mitochondrion organization; negative regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; positive regulation of G protein-coupled receptor signaling pathway; negative regulation of cell growth; osteoblast differentiation; positive regulation of ERK1 and ERK2 cascade; positive regulation of complement activation; negative regulation of ERK1 and ERK2 cascade; progesterone receptor signaling pathway; negative regulation of transcription, DNA-templated; histone deacetylation; signal transduction; negative regulation of cell population proliferation; positive regulation of gene expression; positive regulation of cell death; mitochondrial calcium ion transmembrane transport; ovarian follicle development; ovarian follicle atresia; animal organ regeneration; response to cytokine; response to immobilization stress; negative regulation of apoptotic process; response to peptide hormone; response to ethanol;
	Sources:Amigo / QuickGO
Orthologs
	5245
	18673
	ENSG00000167085
	ENSMUSG00000038845
	P35232
	P67778
	NM_002634; NM_001281496; NM_001281497; NM_001281715
	NM_008831
	NP_001268425; NP_001268426; NP_001268644; NP_002625
	NP_032857
	Wikidata
View/Edit Human	View/Edit Mouse

Prohibitin, also known as PHB, is a protein that in humans is encoded by the PHB gene. The Phb gene has also been described in animals, fungi, plants, and unicellular eukaryotes. Prohibitins are divided in two classes, termed Type-I and Type-II prohibitins, based on their similarity to yeast PHB1 and PHB2, respectively. Each organism has at least one copy of each type of prohibitin gene.