PEPD

PEPD
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2IW2, 2OKN
Identifiers
Aliases	PEPD, PROLIDASE, peptidase D
External IDs	OMIM: 613230; MGI: 97542; HomoloGene: 239; GeneCards: PEPD; OMA:PEPD - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	33,521,791 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	34,744,133 bp
RNA expression pattern
	Top expressed in
	mucosa of ileum; ; human kidney; ; right lobe of liver; ; jejunal mucosa; ; kidney tubule; ; duodenum; ; C1 segment; ; left adrenal cortex; ; stromal cell of endometrium; ; right adrenal cortex;
	Top expressed in
	right kidney; ; intestinal villus; ; jejunum; ; Ileal epithelium; ; proximal tubule; ; human kidney; ; vestibular membrane of cochlear duct; ; duodenum; ; Paneth cell; ; yolk sac;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptidase activity; aminopeptidase activity; protein binding; hydrolase activity; metallopeptidase activity; dipeptidase activity; manganese ion binding; metal ion binding; metallocarboxypeptidase activity; proline dipeptidase activity;
Cellular component	extracellular exosome; nucleus; nucleoplasm;
Biological process	collagen catabolic process; cellular amino acid metabolic process; proteolysis;
	Sources:Amigo / QuickGO
Orthologs
	5184
	18624
	ENSG00000124299
	ENSMUSG00000063931
	P12955
	Q11136
	NM_001166057; NM_000285; NM_001166056
	NM_008820
	NP_000276; NP_001159528; NP_001159529
	NP_032846
	Wikidata
View/Edit Human	View/Edit Mouse

Xaa-Pro dipeptidase, also known as prolidase, is an enzyme that in humans is encoded by the PEPD gene. Prolidase is an enzyme in humans that plays a crucial role in protein metabolism and collagen recycling through the catalysis of the rate-limiting step in these chemical reactions. This enzyme is coded by the gene PEPD (peptidase D), located on chromosome 19. Serum prolidase activity is also currently being explored as a biomarker for diseases.