Propafenone

Propafenone
Clinical data
Pronunciation	/proʊˈpæfɪnoʊn/ proh-PAF-i-nohn
Trade names	Rythmol, Rytmonorm, others
AHFS/Drugs.com	Monograph
MedlinePlus	a698002
License data	US DailyMed: Propafenone;
Routes of; administration	By mouth
ATC code	C01BC03 (WHO) ;
Legal status
Legal status	US: ℞-only;
Pharmacokinetic data
Protein binding	97%
Elimination half-life	2–10 hours
Identifiers
	IUPAC name 1-{2-[2-Hydroxy-3-(propylamino)propoxy]phenyl}-3-phenylpropan-1-one;
CAS Number	54063-53-5 ;
PubChem CID	4932;
IUPHAR/BPS	2561;
DrugBank	DB01182 ;
ChemSpider	4763 ;
UNII	68IQX3T69U;
KEGG	D08435 ;
ChEMBL	ChEMBL631 ;
CompTox Dashboard (EPA)	DTXSID9045184 ;
ECHA InfoCard	100.053.578
Chemical and physical data
Formula	C21H27NO3
Molar mass	341.451 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(c1ccccc1OCC(O)CNCCC)CCc2ccccc2;
	InChI InChI=1S/C21H27NO3/c1-2-14-22-15-18(23)16-25-21-11-7-6-10-19(21)20(24)13-12-17-8-4-3-5-9-17/h3-11,18,22-23H,2,12-16H2,1H3 ; Key:JWHAUXFOSRPERK-UHFFFAOYSA-N ;
	(verify)

Propafenone, sold under the brand name Rythmol among others, is a class 1c anti-arrhythmic medication, which is used to treat illnesses associated with rapid heart beat such as atrial and ventricular arrhythmias.

Clinical data


Pronunciation	/proʊˈpæfɪnoʊn/ proh-PAF-i-nohn
Trade names	Rythmol, Rytmonorm, others
AHFS/Drugs.com	Monograph
MedlinePlus	a698002
License data	US DailyMed: Propafenone
Routes of administration	By mouth
ATC code	C01BC03 (WHO)
Legal status
Legal status	US: ℞-only
Pharmacokinetic data
Protein binding	97%
Elimination half-life	2–10 hours
Identifiers
IUPAC name 1-{2-[2-Hydroxy-3-(propylamino)propoxy]phenyl}-3-phenylpropan-1-one
CAS Number	54063-53-5^Y
PubChem CID	4932
IUPHAR/BPS	2561
DrugBank	DB01182^Y
ChemSpider	4763^Y
UNII	68IQX3T69U
KEGG	D08435^Y
ChEMBL	ChEMBL631^Y
CompTox Dashboard (EPA)	DTXSID9045184
ECHA InfoCard	100.053.578
Chemical and physical data
Formula	C₂₁H₂₇NO₃
Molar mass	341.451 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES O=C(c1ccccc1OCC(O)CNCCC)CCc2ccccc2
InChI InChI=1S/C21H27NO3/c1-2-14-22-15-18(23)16-25-21-11-7-6-10-19(21)20(24)13-12-17-8-4-3-5-9-17/h3-11,18,22-23H,2,12-16H2,1H3^Y Key:JWHAUXFOSRPERK-UHFFFAOYSA-N^Y
(verify)