L-isoaspartyl methyltransferase
| Protein-L-isoaspartate (D-aspartate) O-methyltransferase (PIMT, PCMT) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
Crystallographic structure of Human L-isoaspartyl methyltransferase. | |||||||||
| Identifiers | |||||||||
| EC no. | 2.1.1.77 | ||||||||
| CAS no. | 105638-50-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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| Protein-L-isoaspartate(D-aspartate) O-methyltransferase | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||
| Symbol | PCMT | ||||||||||
| Pfam | PF01135 | ||||||||||
| InterPro | IPR000682 | ||||||||||
| PROSITE | PDOC00985 | ||||||||||
| SCOP2 | 1dl5 / SCOPe / SUPFAM | ||||||||||
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Protein L-isoaspartyl methyltransferase (PIMT, PCMT), also called S-adenosyl-L-methionine:protein-L-isoaspartate O-methyltransferase, is an enzyme which recognizes and catalyzes the repair of damaged L-isoaspartyl and D-aspartyl groups in proteins. It is a highly conserved enzyme which is present in nearly all eukaryotes, archaebacteria, and Gram-negative eubacteria.