QKI

QKI
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4JVH
Identifiers
Aliases	QKI, Hqk, QK, QK1, QK3, hqkI, KH domain containing, RNA binding, KH domain containing RNA binding
External IDs	OMIM: 609590; MGI: 97837; HomoloGene: 11059; GeneCards: QKI; OMA:QKI - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	163,578,592 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	10,538,783 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; dorsal motor nucleus of vagus nerve; ; corpus callosum; ; inferior olivary nucleus; ; inferior ganglion of vagus nerve; ; external globus pallidus; ; pars reticulata; ; subthalamic nucleus; ; superior vestibular nucleus; ; internal globus pallidus;
	Top expressed in
	Gonadal ridge; ; otic placode; ; saccule; ; sciatic nerve; ; left lung lobe; ; deep cerebellar nuclei; ; substantia nigra; ; cumulus cell; ; lateral geniculate nucleus; ; tail of embryo;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	SH3 domain binding; protein binding; nucleic acid binding; mRNA binding; RNA binding;
Cellular component	cytoplasm; nucleus; synapse;
Biological process	cell differentiation; mRNA transport; mRNA processing; vasculogenesis; multicellular organism development; axon ensheathment; muscle cell differentiation; positive regulation of gene expression; long-chain fatty acid biosynthetic process; RNA splicing; spermatid development; myelination; 3'-UTR-mediated mRNA destabilization; regulation of translation; transport;
	Sources:Amigo / QuickGO
Orthologs
	9444
	19317
	ENSG00000112531
	ENSMUSG00000062078
	Q96PU8
	Q9QYS9
	NM_001301085; NM_006775; NM_206853; NM_206854; NM_206855
	NM_001159516; NM_001159517; NM_021881
	NP_001288014; NP_006766; NP_996735; NP_996736; NP_996737
	NP_001152988; NP_001152989; NP_068681
	Wikidata
View/Edit Human	View/Edit Mouse

Quaking homolog, KH domain RNA binding (mouse), also known as QKI, is a protein which in humans is encoded by the QKI gene.

QKI belongs to a family of RNA-binding proteins called STAR proteins for Signal Transduction and Activation of RNA. They have an HNRNPK homology (KH) domain embedded in a 200-amino acid region called the GSG domain. Other members of this family include SAM68 (KHDRBS1) and SF1 . Two more new members are KHDRBS3 and KHDRBS2.

The QKI gene is implicated as being important in schizophrenia, and QKI controls translation of many oligodendrocyte-related genes.