QPCT

QPCT
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2ZEE, 2ZEF, 2AFU, 2AFM, 2AFX, 4YU9, 2ZEL, 2ZEG, 2ZEM, 4YWY, 2AFZ, 3PBB, 2ZEH, 2AFS, 3SI0, 2ZEP, 3PBE, 2ZEO, 2ZED, 2AFO, 2ZEN, 2AFW
Identifiers
Aliases	QPCT, GCT, QC, sQC, glutaminyl-peptide cyclotransferase
External IDs	OMIM: 607065; MGI: 1917786; HomoloGene: 8238; GeneCards: QPCT; OMA:QPCT - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	37,373,322 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	79,397,807 bp
RNA expression pattern
	Top expressed in
	right adrenal cortex; ; beta cell; ; left adrenal gland; ; left adrenal cortex; ; blood; ; bone marrow cells; ; monocyte; ; skin of arm; ; trabecular bone; ; corpus epididymis;
	Top expressed in
	spermatocyte; ; lens; ; lumbar subsegment of spinal cord; ; iris; ; neural layer of retina; ; arcuate nucleus; ; paraventricular nucleus of hypothalamus; ; spermatid; ; seminiferous tubule; ; median eminence;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; zinc ion binding; glutaminyl-peptide cyclotransferase activity; acyltransferase activity; metal ion binding;
Cellular component	extracellular exosome; extracellular region; specific granule lumen; tertiary granule lumen; ficolin-1-rich granule lumen;
Biological process	peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase; neutrophil degranulation;
	Sources:Amigo / QuickGO
Orthologs
	25797
	70536
	ENSG00000115828
	ENSMUSG00000024084
	Q16769
	Q9CYK2
	NM_012413
	NM_027455; NM_001316729
	NP_036545
	NP_001303658; NP_081731
	Wikidata
View/Edit Human	View/Edit Mouse

Glutaminyl-peptide cyclotransferase is an enzyme that in humans is encoded by the QPCT gene.

This gene encodes human pituitary glutaminyl cyclase, which is responsible for the presence of pyroglutamyl residues in many neuroendocrine peptides. The amino acid sequence of this enzyme is 86% identical to that of bovine glutaminyl cyclase.