QRFP

QRFP
Identifiers
Aliases	QRFP, 26RFa, P518, pyroglutamylated RFamide peptide
External IDs	OMIM: 609795; MGI: 3630329; HomoloGene: 52341; GeneCards: QRFP; OMA:QRFP - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	130,896,812 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	31,700,592 bp
RNA expression pattern
	Top expressed in
	testicle; ; gonad; ; mucosa of transverse colon; ; muscle layer of sigmoid colon; ; stromal cell of endometrium; ; popliteal artery; ; tibial arteries; ; sural nerve; ; left coronary artery; ; Descending thoracic aorta;
	Top expressed in
	embryo; ; islet of Langerhans; ; white adipose tissue; ; spermatocyte; ; adrenal gland; ; duodenum; ; lip; ; spleen; ; Hypothalamus; ; uterus;
	More reference expression data
	n/a
Gene ontology
Molecular function	orexigenic neuropeptide QRFP receptor binding; neuropeptide hormone activity;
Cellular component	extracellular region; cellular component;
Biological process	grooming behavior; positive regulation of blood pressure; neuropeptide signaling pathway; regulation of feeding behavior; locomotory behavior; regulation of signaling receptor activity; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	347148
	227717
	ENSG00000188710
	ENSMUSG00000043102
	P83859
	Q8CE23
	NM_198180
	NM_183424
	NP_937823
	NP_906269
	Wikidata
View/Edit Human	View/Edit Mouse

RF(Arg-Phe)amide family 26 amino acid peptide, also known as P518, is a human protein.

The 26-amino acid RF-amide peptide, P518 functions as a high-affinity ligand of GPR103. Both GPR103 and P518 precursor mRNA exhibited highest expression in brain. The 43-amino acid QRFP peptide, a longer form of the P518 peptide is necessary to exhibit full agonistic activity with GPR103. Intravenous administration QRFP caused release of aldosterone, suggesting that QRFP and GPR103 regulate adrenal function.