Methaqualone

Methaqualone
Clinical data
Pronunciation	/mɛθəˈkweɪloʊn/
Trade names	Bon-Sonnil, Dormogen, Dormutil, Mequin, Mozambin, Pro Dorm, Quaalude, Somnotropon, Torinal, Tuazolona; Methaqualone hydrochloride:; Cateudyl, Dormir, Hyptor, Melsed, Melsedin, Mequelon, Methasedil, Nobadorm, Normorest, Noxybel, Optimil, Optinoxan, Pallidan, Parest, Parmilene, Pexaqualone, Renoval, Riporest, Sedalone, Somberol, Somnifac, Somnium, Sopor, Sovelin, Soverin, Sovinal, Toquilone, Toraflon, Tualone, Tuazol
ATC code	N05CM01 (WHO) ;
Legal status
Legal status	AU: S9 (Prohibited substance); BR: Class F2 (Prohibited psychotropics); CA: Schedule III; DE: Anlage II (Authorized trade only, not prescriptible); UK: Class B; US: Schedule I; UN: Psychotropic Schedule II;
Pharmacokinetic data
Protein binding	70–80%
Elimination half-life	Biphasic (10–40; 20–60 hours)
Identifiers
	IUPAC name 2-Methyl-3-o-tolyl-4(3H)-quinazolinone;; 3,4-Dihydro-2-methyl-4-oxo-3-o-tolylquinazoline;; 2-Methyl-3-(2-methylphenyl)-4-(3H)-quinazolinone;
CAS Number	72-44-6 ;
PubChem CID	6292;
DrugBank	DB04833 ;
ChemSpider	6055 ;
UNII	7ZKH8MQW6T;
KEGG	D00557 ;
ChEBI	CHEBI:6821;
ChEMBL	ChEMBL282052 ;
CompTox Dashboard (EPA)	DTXSID7023279 ;
ECHA InfoCard	100.000.710
Chemical and physical data
Formula	C16H14N2O
Molar mass	250.301 g·mol−1
3D model (JSmol)	Interactive image;
Melting point	113 °C (235 °F)
	SMILES Cc1ccccc1-n1c(C)nc2ccccc2c1=O;
	InChI InChI=1S/C16H14N2O/c1-11-7-3-6-10-15(11)18-12(2)17-14-9-5-4-8-13(14)16(18)19/h3-10H,1-2H3 ; Key:JEYCTXHKTXCGPB-UHFFFAOYSA-N ;
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Methaqualone is a hypnotic sedative. It was sold under the brand names Quaalude (/ˈkweɪluːd/ KWAY-lood) and Sopor among others, which contained 300 mg of methaqualone, and sold as a combination drug under the brand name Mandrax, which contained 250 mg methaqualone and 25 mg diphenhydramine within the same tablet, mostly in Europe. Commercial production of methaqualone was halted in the mid-1980s due to widespread abuse and addictiveness. It is a member of the quinazolinone class.