Quazepam

Quazepam
Clinical data
Trade names	Doral
AHFS/Drugs.com	Monograph
MedlinePlus	a684001
Pregnancy; category	AU: D;
Routes of; administration	By mouth
ATC code	N05CD10 (WHO) ;
Legal status
Legal status	CA: Schedule IV; US: Schedule IV;
Pharmacokinetic data
Bioavailability	29–35%
Metabolism	Liver
Elimination half-life	39 hours
Excretion	Kidney
Identifiers
	IUPAC name 7-chloro-5-(2-fluorophenyl)-1-(2,2,2-trifluoroethyl)-3H-1,4-benzodiazepine-2-thione;
CAS Number	36735-22-5 ;
PubChem CID	4999;
IUPHAR/BPS	7288;
DrugBank	DB01589 ;
ChemSpider	4825 ;
UNII	JF8V0828ZI;
KEGG	D00457 ;
ChEMBL	ChEMBL1200472 ;
CompTox Dashboard (EPA)	DTXSID60190193 ;
ECHA InfoCard	100.048.329
Chemical and physical data
Formula	C17H11ClF4N2S
Molar mass	386.79 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES FC(F)(F)CN1C(=S)C/N=C(\c2cc(Cl)ccc12)c3ccccc3F;
	InChI InChI=1S/C17H11ClF4N2S/c18-10-5-6-14-12(7-10)16(11-3-1-2-4-13(11)19)23-8-15(25)24(14)9-17(20,21)22/h1-7H,8-9H2 ; Key:IKMPWMZBZSAONZ-UHFFFAOYSA-N ;
	(what is this?) (verify)

Quazepam, sold under the brand name Doral among others, is a relatively long-acting benzodiazepine derivative drug developed by the Schering Corporation in the 1970s. Quazepam is used for the treatment of insomnia, including sleep induction and sleep maintenance. Quazepam induces impairment of motor function and has relatively (and uniquely) selective hypnotic and anticonvulsant properties with considerably less overdose potential than other benzodiazepines (due to its novel receptor-subtype selectivity). Quazepam is an effective hypnotic which induces and maintains sleep without disruption of the sleep architecture.

It was patented in 1970 and came into medical use in 1985.