Que Sera Sera is the fourth studio album by Johnny Thunders, former lead guitarist of the New York Dolls and The Heartbreakers, released in December 1985. Unlike previous efforts So Alone and In Cold Blood, only one song on the album features members of his former bands, and Thunders instead relied largely on the reggae-influenced rhythm section of session musicians Keith George Yon and Tony St. Helene, nicknamed the Black Cats, and also features contributions from Dr. Feelgood guitarist Wilko Johnson, long-term collaborator Patti Palladin, and members of Hanoi Rocks.
The original 1985 release of the album had ten songs. On later pressings, other songs from the sessions were added, "Que Sera, Sera", "Cool Operator (Black Cat Remix)" and Thunders' own remix of the opening track, "Short Lives", which replaced the original mix as opener of the album. "Que Sera, Sera" was first released as a single (7" and 12"), backed with Thunders' remix of "Short Lives". "Tie Me Up" was earlier released as B-side to the Johnny Thunders and Patti Palladin single, a cover of Elvis Presley's song "Crawfish" in 1985.