Sign of Hertoghe

Sign of Hertoghe
Other namesQueen Anne's sign
Anne of Denmark mourning the death of her son Henry in 1612
CausesHypothyroidism, atopic dermatitis
Named afterEugene Ludovic Christian Hertoghe

The sign of Hertoghe or Queen Anne's sign is a type of madarosis, more specifically a thinning or loss of the outer third of the eyebrows, and may appear in severe hypothyroidism or atopic dermatitis. It was also observed in lepromatous leprosy, secondary syphilis, hypoparathyroidism, poisoning with either lead or thallium, lupus, or normal aging.

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