6,7-dihydropteridine reductase
| 6,7-dihydropteridine reductase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
Dihydropteridine reductase dimer, Human | |||||||||
| Identifiers | |||||||||
| EC no. | 1.5.1.34 | ||||||||
| CAS no. | 9074-11-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, 6,7-dihydropteridine reductase (EC 1.5.1.34, also Dihydrobiopterin reductase) is an enzyme that catalyzes the chemical reaction
- 5,6,7,8-tetrahydropteridine + NAD(P)+ 6,7-dihydropteridine + NAD(P)H + H+
The four substrates for this enzyme are a 6,7-dihydropteridine (dihydrobiopterin), NADH, NADPH, and H+ and its three products are 5,6,7,8-tetrahydropteridine (tetrahydrobiopterin), NAD+, and NADP+ This enzyme participates in folate biosynthesis. In the human genome, the enzyme is encoded by the QDPR gene.