RAB2B

RAB2B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2A5J
Identifiers
Aliases	RAB2B, member RAS oncogene family, RAB protein-GTP binding protein- RAS protein
External IDs	OMIM: 607466; MGI: 1923588; HomoloGene: 23789; GeneCards: RAB2B; OMA:RAB2B - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	21,476,960 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	52,517,002 bp
RNA expression pattern
	Top expressed in
	pancreatic ductal cell; ; mucosa of ileum; ; Achilles tendon; ; secondary oocyte; ; trabecular bone; ; bone marrow; ; ganglionic eminence; ; skin of thigh; ; skin of arm; ; islet of Langerhans;
	Top expressed in
	fossa; ; substantia nigra; ; internal carotid artery; ; external carotid artery; ; motor neuron; ; trigeminal ganglion; ; condyle; ; sciatic nerve; ; epithelium of lens; ; ureter;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; GTP binding; protein binding; GTPase activity;
Cellular component	plasma membrane; Golgi apparatus; extracellular exosome; endoplasmic reticulum membrane; endoplasmic reticulum; membrane; Golgi membrane; presynapse;
Biological process	protein transport; positive regulation of exocytosis; vesicle-mediated transport; transport; intracellular protein transport; Rab protein signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	84932
	76338
	ENSG00000129472
	ENSMUSG00000022159
	Q8WUD1
	P59279
	NM_001163380; NM_032846
	NM_172601
	NP_001156852; NP_116235
	NP_766189
	Wikidata
View/Edit Human	View/Edit Mouse

Ras-related protein Rab-2B is a protein that in humans is encoded by the RAB2B gene.

RAB2B is required for protein transport from the endoplasmic reticulum to the Golgi complex. It belongs to the small GTPase superfamily, specifically to the RAB protein family. Small GTPases are a type of hydrolase enzymes that can attach to a GTP to form a GDP. This process makes small GTPases active when bonded to a GTP and inactive when bonded to a GDP. Inside this small GTPase superfamily we can find the RAS subfamily. This family is divided into 5 groups: Ras, Rho, Ran, Rab and Arf GTPases. RAB2B’s main function is regulating vesicle transport and membrane fusion.