RAB3GAP2

RAB3GAP2
Identifiers
Aliases	RAB3GAP2, RAB3-GAP150, RAB3GAP150, SPG69, WARBM2, p150, RAB3 GTPase activating non-catalytic protein subunit 2, MARTS1
External IDs	OMIM: 609275; MGI: 1916043; HomoloGene: 40842; GeneCards: RAB3GAP2; OMA:RAB3GAP2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	220,272,529 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	185,018,956 bp
RNA expression pattern
	Top expressed in
	Epithelium of choroid plexus; ; lateral nuclear group of thalamus; ; spinal ganglia; ; pericardium; ; trigeminal ganglion; ; Pons; ; Brodmann area 46; ; cardia; ; beta cell; ; endothelial cell;
	Top expressed in
	zygote; ; secondary oocyte; ; granulocyte; ; dentate gyrus of hippocampal formation granule cell; ; substantia nigra; ; facial motor nucleus; ; primary oocyte; ; superior frontal gyrus; ; primary visual cortex; ; decidua;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	enzyme regulator activity; enzyme activator activity; GTPase activator activity; protein heterodimerization activity; protein binding;
Cellular component	plasma membrane; endoplasmic reticulum membrane; cytoplasm; cytosol; protein-containing complex;
Biological process	regulation of GTPase activity; positive regulation of protein lipidation; establishment of protein localization to endoplasmic reticulum membrane; intracellular protein transport; positive regulation of autophagosome assembly; positive regulation of endoplasmic reticulum tubular network organization; positive regulation of catalytic activity; positive regulation of GTPase activity;
	Sources:Amigo / QuickGO
Orthologs
	25782
	98732
	ENSG00000118873
	ENSMUSG00000039318
	Q9H2M9
	Q8BMG7
	NM_012414
	NM_001163754; NM_172649
	NP_036546
	NP_001157226; NP_001392257
	Wikidata
View/Edit Human	View/Edit Mouse

Rab3 GTPase-activating protein non-catalytic subunit is an enzyme that in humans is encoded by the RAB3GAP2 gene.

Members of the RAB3 protein family (see RAB3A; MIM 179490) are implicated in Ca(2+)-dependent exocytosis. RAB3GAP, which is involved in regulation of RAB3 activity, is a heterodimeric complex consisting a 130-kD catalytic subunit (RAB3GAP1; MIM 602536) and a 150-kD noncatalytic subunit (RAB3GAP2) (Nagano et al., 1998).[supplied by OMIM]