RAB7A

RAB7A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1T91, 1YHN, 3LAW
Identifiers
Aliases	RAB7A, PRO2706, RAB7, member RAS oncogene family, CMT2B
External IDs	OMIM: 602298; MGI: 105068; HomoloGene: 3408; GeneCards: RAB7A; OMA:RAB7A - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	128,825,942 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	88,022,252 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; right lung; ; C1 segment; ; monocyte; ; gastrocnemius muscle; ; prefrontal cortex; ; right adrenal cortex; ; muscle of thigh; ; left adrenal gland; ; epithelium of colon;
	Top expressed in
	secondary oocyte; ; zygote; ; primary oocyte; ; tail of embryo; ; genital tubercle; ; granulocyte; ; muscle of thigh; ; dentate gyrus of hippocampal formation granule cell; ; hippocampus proper; ; skeletal muscle tissue;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; GTP binding; protein binding; retromer complex binding; GTPase activity; GDP binding;
Cellular component	cytoplasm; phagophore assembly site membrane; endosome; phagocytic vesicle membrane; Golgi apparatus; late endosome; membrane; late endosome membrane; extrinsic component of lysosome membrane; lipid droplet; melanosome membrane; retromer complex; lysosomal membrane; autophagosome membrane; phagocytic vesicle; lysosome; extracellular exosome; cytoplasmic vesicle; cytosol; plasma membrane; endosome membrane; secretory granule membrane; terminal bouton; alveolar lamellar body; vacuolar membrane; intracellular anatomical structure;
Biological process	protein to membrane docking; protein targeting to lysosome; lipophagy; viral release from host cell; positive regulation of protein catabolic process; phagosome-lysosome fusion; endocytosis; antigen processing and presentation of exogenous peptide antigen via MHC class II; lipid metabolism; endosome to lysosome transport; phagosome acidification; autophagy; lipid catabolic process; phagosome maturation; early endosome to late endosome transport; retrograde transport, endosome to Golgi; protein transport; positive regulation of exosomal secretion; epidermal growth factor catabolic process; positive regulation of viral process; neutrophil degranulation; negative regulation of exosomal secretion; negative regulation of intralumenal vesicle formation; autophagosome assembly; bone resorption; transport; intracellular protein transport; Rab protein signal transduction; small GTPase mediated signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	7879
	19349
	ENSG00000075785
	ENSMUSG00000079477
	P51149
	P51150
	NM_004637
	NM_001293652; NM_001293653; NM_001293654; NM_001293655; NM_009005
	NP_004628
	NP_001280581; NP_001280582; NP_001280583; NP_001280584; NP_033031
	Wikidata
View/Edit Human	View/Edit Mouse

Ras-related protein Rab-7a is a protein that in humans is encoded by the RAB7A gene.

Ras-related protein Rab-7a is involved in endocytosis, which is a process that brings substances into a cell. The process of endocytosis works by folding the cell membrane around a substance outside of the cell (for example a protein) and then forms a vesicle. The vesicle is then brought into the cell and cleaved from the cell membrane. RAB7A plays an important role in the movement of vesicles into the cell as well as with vesicle trafficking.

Various mutations of RAB7A are associated with Hereditary sensory neuropathy type 1C (HSN IC), also known as Charcot-Marie-Tooth syndrome type 2B (CMT2B).