RAC2

RAC2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1DS6, 2W2T, 2W2V, 2W2X
Identifiers
Aliases	RAC2, EN-7, Gx, HSPC022, p21-Rac2, ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2), Rac family small GTPase 2, IMD73B, IMD73C, IMD73A
External IDs	OMIM: 602049; MGI: 97846; HomoloGene: 55699; GeneCards: RAC2; OMA:RAC2 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	37,244,448 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	78,456,983 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; blood; ; spleen; ; bone marrow; ; bone marrow cells; ; appendix; ; monocyte; ; trabecular bone; ; thymus; ; lymph node;
	Top expressed in
	granulocyte; ; tibiofemoral joint; ; thymus; ; spleen; ; mesenteric lymph nodes; ; blood; ; ankle joint; ; fetal liver hematopoietic progenitor cell; ; bone marrow; ; stroma of bone marrow;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; GTP binding; protein kinase regulator activity; GTPase activity; protein binding;
Cellular component	cytoplasm; cytosol; phagocytic vesicle membrane; nuclear envelope; membrane; focal adhesion; plasma membrane; actin filament; extracellular exosome; lamellipodium; intracellular anatomical structure;
Biological process	regulation of respiratory burst; lymphocyte aggregation; regulation of T cell proliferation; positive regulation of protein targeting to mitochondrion; regulation of hydrogen peroxide metabolic process; actin filament organization; regulation of cell-substrate adhesion; regulation of neutrophil migration; bone resorption; platelet activation; chemotaxis; cell projection assembly; positive regulation of cell population proliferation; regulation of mast cell chemotaxis; positive regulation of neutrophil chemotaxis; regulation of mast cell degranulation; regulation of protein kinase activity; positive regulation of lamellipodium assembly; regulation of small GTPase mediated signal transduction; actin cytoskeleton organization; signal transduction; small GTPase mediated signal transduction; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	5880
	19354
	ENSG00000128340
	ENSMUSG00000033220
	P15153
	Q05144
	NM_002872
	NM_009008
	NP_002863
	NP_033034
	Wikidata
View/Edit Human	View/Edit Mouse

Rac2 (Ras-related C3 botulinum toxin substrate 2) is a small (~21 kDa) signaling G protein (to be specific, a GTPase), and is a member of the Rac subfamily of the family Rho family of GTPases. It is encoded by the gene RAC2.

Members of Rho family of GTPases appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases.