RAC3

RAC3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2C2H, 2G0N, 2IC5, 2OV2, 2QME
Identifiers
Aliases	RAC3, ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3), Rac family small GTPase 3
External IDs	OMIM: 602050; MGI: 2180784; HomoloGene: 68433; GeneCards: RAC3; OMA:RAC3 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	82,034,204 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	120,614,795 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; ganglionic eminence; ; ventricular zone; ; right frontal lobe; ; right testis; ; cingulate gyrus; ; anterior cingulate cortex; ; left testis; ; prefrontal cortex; ; anterior pituitary;
	Top expressed in
	dorsomedial hypothalamic nucleus; ; lip; ; dentate gyrus of hippocampal formation granule cell; ; ventromedial nucleus; ; neural tube; ; secondary oocyte; ; superior frontal gyrus; ; primary visual cortex; ; lateral hypothalamus; ; embryo;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; GTP binding; calcium-dependent protein binding; protein binding; GTPase activity; protein kinase binding;
Cellular component	cytoplasm; filamentous actin; cytosol; cell projection; membrane; growth cone; plasma membrane; soma; perinuclear region of cytoplasm; neuron projection; extracellular exosome; cytoskeleton; endomembrane system; cell periphery; lamellipodium; intracellular anatomical structure;
Biological process	intracellular signal transduction; neuromuscular process controlling balance; regulation of neuron maturation; synaptic transmission, GABAergic; cerebral cortex GABAergic interneuron development; positive regulation of substrate adhesion-dependent cell spreading; neuromuscular process; cell projection assembly; regulation of cell morphogenesis; homeostasis of number of cells within a tissue; positive regulation of cell adhesion mediated by integrin; neuron projection development; regulation of small GTPase mediated signal transduction; actin cytoskeleton organization; small GTPase mediated signal transduction; cell morphogenesis; actin filament organization; Rho protein signal transduction; cell migration; positive regulation of actin filament polymerization; actin cytoskeleton reorganization; engulfment of apoptotic cell;
	Sources:Amigo / QuickGO
Orthologs
	5881
	170758
	ENSG00000169750
	ENSMUSG00000018012
	P60763
	P60764
	NM_005052; NM_001316307
	NM_133223
	NP_001303236; NP_005043
	NP_573486
	Wikidata
View/Edit Human	View/Edit Mouse

Ras-related C3 botulinum toxin substrate 3 (Rac3) is a G protein that in humans is encoded by the RAC3 gene. It is an important component of intracellular signalling pathways. Rac3 is a member of the Rac subfamily of the Rho family of small G proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases.