RAD18

RAD18
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2MRE, 2MRF, 2Y43, 2YBF
Identifiers
Aliases	RAD18, RNF73, E3 ubiquitin protein ligase, RAD18 E3 ubiquitin protein ligase
External IDs	OMIM: 605256; MGI: 1890476; HomoloGene: 48572; GeneCards: RAD18; OMA:RAD18 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	8,963,773 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	112,673,647 bp
RNA expression pattern
	Top expressed in
	testicle; ; Achilles tendon; ; ventricular zone; ; gonad; ; ganglionic eminence; ; jejunal mucosa; ; stromal cell of endometrium; ; epithelium of colon; ; islet of Langerhans; ; bone marrow cells;
	Top expressed in
	tail of embryo; ; zygote; ; spermatocyte; ; genital tubercle; ; spermatid; ; secondary oocyte; ; primary oocyte; ; epiblast; ; lumbar spinal ganglion; ; inner renal medulla;
	More reference expression data
	n/a
Gene ontology
Molecular function	metal ion binding; polyubiquitin modification-dependent protein binding; Y-form DNA binding; ubiquitin protein ligase activity; damaged DNA binding; DNA binding; ubiquitin protein ligase binding; single-stranded DNA helicase activity; protein binding; identical protein binding; transferase activity; protein-containing complex binding; single-stranded DNA binding;
Cellular component	cytoplasm; site of double-strand break; microtubule organizing center; nucleus; replication fork; centrosome; Rad6-Rad18 complex; nuclear inclusion body; cytoskeleton; nucleoplasm; nuclear body;
Biological process	protein monoubiquitination; response to UV; negative regulation of cell death; positive regulation of chromosome segregation; cellular response to DNA damage stimulus; postreplication repair; protein autoubiquitination; DNA repair; protein ubiquitination;
	Sources:Amigo / QuickGO
Orthologs
	56852
	58186
	ENSG00000070950
	ENSMUSG00000030254
	Q9NS91
	Q9QXK2
	NM_020165
	NM_001167730; NM_021385; NM_001381931; NM_001381932; NM_001381933
	NP_064550
	NP_001161202; NP_067360; NP_001368860; NP_001368861; NP_001368862
	Wikidata
View/Edit Human	View/Edit Mouse

E3 ubiquitin-protein ligase RAD18 is an enzyme that in humans is encoded by the RAD18 gene. A knockout in a human colorectal cancer cell line, HCT116, has also been created.