RAD54L

RAD54L
Identifiers
Aliases	RAD54L, HR54, RAD54A, hHR54, hRAD54, RAD54-like (S. cerevisiae), RAD54 like (S. cerevisiae), RAD54 like
External IDs	OMIM: 603615; MGI: 894697; HomoloGene: 48227; GeneCards: RAD54L; OMA:RAD54L - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	46,278,480 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	115,980,887 bp
RNA expression pattern
	Top expressed in
	left testis; ; right testis; ; ventricular zone; ; ganglionic eminence; ; gonad; ; testicle; ; mucosa of transverse colon; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; gastrocnemius muscle;
	Top expressed in
	primitive streak; ; otic placode; ; otic vesicle; ; tail of embryo; ; tibiofemoral joint; ; maxillary prominence; ; mandibular prominence; ; fetal liver hematopoietic progenitor cell; ; epiblast; ; genital tubercle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	ATP-dependent DNA/DNA annealing activity; DNA binding; nucleotide binding; protein binding; hydrolase activity; ATP binding; helicase activity;
Cellular component	nucleoplasm; nucleus; protein-containing complex;
Biological process	response to ionizing radiation; DNA recombination; double-strand break repair; double-strand break repair via homologous recombination; determination of adult lifespan; chromosome organization; cellular response to DNA damage stimulus; DNA repair; meiosis;
	Sources:Amigo / QuickGO
Orthologs
	8438
	19366
	ENSG00000085999
	ENSMUSG00000028702
	Q92698
	P70270
	NM_001142548; NM_003579; NM_001370766
	NM_001122958; NM_001122959; NM_009015
	NP_001136020; NP_003570; NP_001357695
	NP_001116430; NP_001116431; NP_033041
	Wikidata
View/Edit Human	View/Edit Mouse

DNA repair and recombination protein RAD54-like is a protein that in humans is encoded by the RAD54L gene.

The protein encoded by this gene belongs to the DEAD-like helicase superfamily, and shares similarity with Saccharomyces cerevisiae Rad54, a protein known to be involved in the homologous recombination and repair of DNA. This protein has been shown to play a role in homologous recombination related repair of DNA double-strand breaks. The binding of this protein to double-strand DNA induces a DNA topological change, which is thought to facilitate homologous DNA pairing, and stimulate DNA recombination.

RAD54 is one of the key proteins necessary for homologous recombination and DNA repair in many organisms. Without functional RAD54, tumor development is more likely. RAD54 was initially described in the budding yeast Saccharomyces cerevisiae as being a member of the evolutionarily conserved RAD52 epistasis group, which additionally includes RAD51, RAD52, RAD55, and RAD57 factors. This group is believed to be involved in DNA recombination events and repair mechanisms, especially those involving double-stranded DNA breaks during both mitosis and meiosis. Recently a human homologue of the yeast RAD54 was discovered and termed hRAD54.