RAD9A

RAD9A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3A1J, 3G65, 3GGR
Identifiers
Aliases	RAD9A, RAD9, RAD9 checkpoint clamp component A
External IDs	OMIM: 603761; MGI: 1328356; HomoloGene: 32118; GeneCards: RAD9A; OMA:RAD9A - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	67,398,410 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	4,251,661 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; olfactory zone of nasal mucosa; ; granulocyte; ; mucosa of transverse colon; ; right lobe of thyroid gland; ; anterior pituitary; ; left lobe of thyroid gland; ; minor salivary glands; ; skin of leg; ; canal of the cervix;
	Top expressed in
	genital tubercle; ; tail of embryo; ; granulocyte; ; bone marrow; ; epiblast; ; spleen; ; thymus; ; embryo; ; embryo; ; blastocyst;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	SH3 domain binding; histone deacetylase binding; exodeoxyribonuclease III activity; protein binding; 3'-5' exonuclease activity; enzyme binding; nuclease activity; exonuclease activity; hydrolase activity; protein kinase binding;
Cellular component	cytoplasm; nucleoplasm; checkpoint clamp complex; nucleus;
Biological process	cell cycle checkpoint signaling; mitotic intra-S DNA damage checkpoint signaling; DNA damage checkpoint signaling; cellular response to DNA damage stimulus; DNA replication checkpoint signaling; positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage; cellular response to ionizing radiation; nucleic acid phosphodiester bond hydrolysis; DNA repair; DNA replication; regulation of signal transduction by p53 class mediator;
	Sources:Amigo / QuickGO
Orthologs
	5883
	19367
	ENSG00000172613
	ENSMUSG00000024824
	Q99638
	Q9Z0F6
	NM_001243224; NM_004584
	NM_011237
	NP_001230153; NP_004575
	NP_035367
	Wikidata
View/Edit Human	View/Edit Mouse

Cell cycle checkpoint control protein RAD9A is a protein that in humans is encoded by the RAD9A gene.Rad9 has been shown to induce G2 arrest in the cell cycle in response to DNA damage in yeast cells. Rad9 was originally found in budding yeast cells but a human homolog has also been found and studies have suggested that the molecular mechanisms of the S and G2 checkpoints are conserved in eukaryotes. Thus, what is found in yeast cells are likely to be similar in human cells.