RAE1

RAE1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3MMY, 4OWR
Identifiers
Aliases	RAE1, MIG14, MRNP41, Mnrp41, dJ481F12.3, dJ800J21.1, ribonucleic acid export 1, Gle2
External IDs	OMIM: 603343; MGI: 1913929; HomoloGene: 2676; GeneCards: RAE1; OMA:RAE1 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	57,379,211 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	172,857,532 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; sperm; ; left testis; ; right testis; ; tendon of biceps brachii; ; internal globus pallidus; ; embryo; ; trabecular bone; ; ganglionic eminence; ; bone marrow;
	Top expressed in
	otic placode; ; spermatocyte; ; saccule; ; otic vesicle; ; spermatid; ; epiblast; ; zygote; ; embryo; ; mandibular prominence; ; ventricular zone;
	More reference expression data
	n/a
Gene ontology
Molecular function	microtubule binding; RNA binding; protein binding; ubiquitin binding;
Cellular component	cytoplasm; nuclear pore; nucleus; nuclear envelope; fibrillar center; mitotic spindle pole; spindle pole; cytoskeleton; host cell;
Biological process	cellular response to organic cyclic compound; viral process; regulation of mitotic spindle organization; transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery; RNA export from nucleus; protein import into nucleus; cell cycle; cell division; mRNA export from nucleus; regulation of glycolytic process; tRNA export from nucleus; protein sumoylation; viral transcription; regulation of gene silencing by miRNA; intracellular transport of virus; regulation of cellular response to heat;
	Sources:Amigo / QuickGO
Orthologs
	8480
	66679
	ENSG00000101146
	ENSMUSG00000027509
	P78406
	Q8C570
	NM_001015885; NM_003610
	NM_175112
	NP_001015885; NP_003601
	NP_780321
	Wikidata
View/Edit Human	View/Edit Mouse

mRNA export factor is a protein that in humans is encoded by the RAE1 gene.

Mutations in the Schizosaccharomyces pombe Rae1 and Saccharomyces cerevisiae Gle2 genes have been shown to result in accumulation of poly(A)-containing mRNA in the nucleus, suggesting that the encoded proteins are involved in RNA export. The protein encoded by this gene is a homolog of yeast Rae1. It contains four WD40 motifs, and has been shown to localize to distinct foci in the nucleoplasm, to the nuclear rim, and to meshwork-like structures throughout the cytoplasm. This gene is thought to be involved in nucleocytoplasmic transport, and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton. Alternatively spliced transcript variants encoding the same protein have been found for this gene.