RALB

RALB
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2KE5, 2KWI
Identifiers
Aliases	RALB, RAS like proto-oncogene B
External IDs	OMIM: 179551; MGI: 1927244; HomoloGene: 20632; GeneCards: RALB; OMA:RALB - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	120,294,710 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	119,432,524 bp
RNA expression pattern
	Top expressed in
	monocyte; ; blood; ; rectum; ; gallbladder; ; cingulate gyrus; ; oral cavity; ; anterior cingulate cortex; ; visceral pleura; ; smooth muscle tissue; ; granulocyte;
	Top expressed in
	granulocyte; ; epithelium of stomach; ; endocardial cushion; ; left lung lobe; ; atrium; ; genital tubercle; ; yolk sac; ; cumulus cell; ; umbilical cord; ; placenta;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; GDP binding; ATPase binding; GTP binding; protein binding; GTPase activity; ubiquitin protein ligase binding;
Cellular component	membrane; plasma membrane; autophagosome; exocyst; extracellular exosome; intracellular anatomical structure; midbody;
Biological process	positive regulation of protein phosphorylation; positive regulation of autophagosome assembly; cellular response to starvation; negative regulation of protein binding; positive regulation of protein serine/threonine kinase activity; cell division; regulation of exocyst assembly; cellular response to exogenous dsRNA; cell cycle; positive regulation of protein binding; signal transduction; regulation of exocyst localization; apoptotic process; Ras protein signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	5899
	64143
	ENSG00000144118
	ENSMUSG00000004451
	P11234
	Q9JIW9
	NM_002881; NM_001369400
	NM_022327
	NP_002872; NP_001356329
	NP_071722
	Wikidata
View/Edit Human	View/Edit Mouse

Ras-related protein Ral-B (RalB) is a protein that in humans is encoded by the RALB gene on chromosome 2. This protein is one of two paralogs of the Ral protein, the other being RalA, and part of the Ras GTPase family. RalA functions as a molecular switch to activate a number of biological processes, majorly cell division and transport, via signaling pathways. Its biological role thus implicates it in many cancers.