RANBP1

RANBP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1K5D, 1K5G
Identifiers
Aliases	RANBP1, HTF9A, RAN binding protein 1
External IDs	OMIM: 601180; MGI: 96269; HomoloGene: 21600; GeneCards: RANBP1; OMA:RANBP1 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	20,127,355 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	18,066,596 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; ventricular zone; ; left testis; ; right testis; ; mucosa of transverse colon; ; prefrontal cortex; ; cerebellar hemisphere; ; anterior cingulate cortex; ; right hemisphere of cerebellum; ; left uterine tube;
	Top expressed in
	yolk sac; ; epiblast; ; embryo; ; tail of embryo; ; embryo; ; genital tubercle; ; ventricular zone; ; neural tube; ; Mesencephalon; ; ganglionic eminence;
	More reference expression data
	n/a
Gene ontology
Molecular function	GTPase activator activity; GDP-dissociation inhibitor activity; protein binding; cadherin binding;
Cellular component	cytoplasm; nuclear envelope; nucleus; centrosome; cytosol; nuclear pore;
Biological process	positive regulation of GTPase activity; intracellular transport; viral process; signal transduction; ubiquitin-dependent protein catabolic process; regulation of catalytic activity; protein import into nucleus; spindle organization; positive regulation of mitotic centrosome separation; RNA export from nucleus; G1/S transition of mitotic cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	5902
	19385
	ENSG00000099901
	ENSMUSG00000005732
	P43487
	P34022
	NM_001278639; NM_001278640; NM_001278641; NM_002882
	NM_011239
	NP_001265568; NP_001265569; NP_001265570; NP_002873
	NP_035369
	Wikidata
View/Edit Human	View/Edit Mouse

Ran-specific binding protein 1 is an enzyme that in humans is encoded by the RANBP1 gene.

Ran/TC4-binding protein, RanBP1, interacts specifically with GTP-charged RAN. RANBP1 encodes a 23-kD protein that binds to RAN complexed with GTP but not GDP. RANBP1 does not activate GTPase activity of RAN but does markedly increase GTP hydrolysis by the RanGTPase-activating protein (RANGAP1). The RANBP1 cDNA encodes a 201-amino acid protein that is 92% similar to its mouse homolog. In both mammalian cells and in yeast, RANBP1 acts as a negative regulator of RCC1 by inhibiting RCC1-stimulated guanine nucleotide release from RAN.