RAP1A

RAP1A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1C1Y, 1GUA, 3KUC, 4KVG
Identifiers
Aliases	RAP1A, C21KG, G-22K, KREV-1, KREV1, RAP1, SMGP21, member of RAS oncogene family
External IDs	OMIM: 179520; MGI: 97852; HomoloGene: 2162; GeneCards: RAP1A; OMA:RAP1A - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	111,716,691 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	105,708,652 bp
RNA expression pattern
	Top expressed in
	monocyte; ; tail of epididymis; ; superficial temporal artery; ; popliteal artery; ; tibial arteries; ; jejunal mucosa; ; muscle layer of sigmoid colon; ; gastric mucosa; ; saphenous vein; ; right ventricle;
	Top expressed in
	tail of embryo; ; genital tubercle; ; jejunum; ; granulocyte; ; esophagus; ; stomach; ; thymus; ; placenta; ; dentate gyrus of hippocampal formation granule cell; ; duodenum;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; protein-containing complex binding; GTP binding; protein binding; GTPase activity; GDP binding;
Cellular component	cytosol; endosome; membrane; myelin sheath; plasma membrane; guanyl-nucleotide exchange factor complex; neuron projection; extracellular exosome; early endosome; late endosome; cytoplasm; cell junction; perinuclear region of cytoplasm; specific granule membrane; phagocytic vesicle; glutamatergic synapse;
Biological process	establishment of endothelial barrier; positive regulation of glucose import; microvillus assembly; regulation of cell junction assembly; regulation of insulin secretion; small GTPase mediated signal transduction; Rap protein signal transduction; cellular response to organic cyclic compound; nervous system development; negative regulation of synaptic vesicle exocytosis; liver regeneration; protein transport; response to antineoplastic agent; response to carbohydrate; negative regulation of collagen biosynthetic process; cellular response to glucose stimulus; signal transduction; cellular response to nerve growth factor stimulus; nerve growth factor signaling pathway; positive regulation of ERK1 and ERK2 cascade; positive regulation of protein kinase activity; positive regulation of vasculogenesis; positive regulation of GTPase activity; cellular response to cAMP; positive regulation of neuron projection development; neutrophil degranulation; positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane; protein localization to plasma membrane;
	Sources:Amigo / QuickGO
Orthologs
	5906
	109905
	ENSG00000116473
	ENSMUSG00000068798
	P62834
	P62835
NM_001010935; NM_001291896; NM_002884; NM_001370216; NM_001370217;
	NM_001394066
	NM_145541
	NP_001010935; NP_001278825; NP_002875; NP_001357145; NP_001357146
	NP_663516
	Wikidata
View/Edit Human	View/Edit Mouse

Ras-related protein Rap-1A is a protein that in humans is encoded by the RAP1A gene.