RAP1GAP2

RAP1GAP2
Identifiers
Aliases	RAP1GAP2, GARNL4, RAP1GA3, RAP1 GTPase activating protein 2
External IDs	MGI: 3028623; HomoloGene: 56695; GeneCards: RAP1GAP2; OMA:RAP1GAP2 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	3,037,741 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	74,501,741 bp
RNA expression pattern
	Top expressed in
	Brodmann area 23; ; middle temporal gyrus; ; endothelial cell; ; superior frontal gyrus; ; right hemisphere of cerebellum; ; islet of Langerhans; ; postcentral gyrus; ; cerebellar vermis; ; entorhinal cortex; ; beta cell;
	Top expressed in
	islet of Langerhans; ; primary motor cortex; ; medial vestibular nucleus; ; submandibular gland; ; prefrontal cortex; ; deep cerebellar nuclei; ; cingulate gyrus; ; pontine nuclei; ; dentate gyrus of hippocampal formation granule cell; ; epithelium of stomach;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; GTPase activator activity;
Cellular component	perinuclear region of cytoplasm; neuron projection; centrosome; plasma membrane; nuclear membrane; cytoplasm; cytosol;
Biological process	regulation of cell size; positive regulation of GTPase activity; negative regulation of neuron projection development; regulation of small GTPase mediated signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	23108
	380711
	ENSG00000132359
	ENSMUSG00000038807
	Q684P5
	Q5SVL6
	NM_001100398; NM_015085; NM_001330058
	NM_001015046; NM_001364131; NM_001364132
	NP_001093868; NP_001316987; NP_055900
	NP_001015046; NP_001351060; NP_001351061; NP_001388587
	Wikidata
View/Edit Human	View/Edit Mouse

RAP1 GTPase activating protein 2 is a protein in humans that is encoded by the RAP1GAP2 gene.

This gene encodes a GTPase-activating protein that activates the small guanine-nucleotide-binding protein Rap1 in platelets. The protein interacts with synaptotagmin-like protein 1 and Rab27 and regulates secretion of dense granules from platelets at sites of endothelial damage. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009].