RAPGEF1

RAPGEF1
Identifiers
Aliases	RAPGEF1, C3G, GRF2, Rap guanine nucleotide exchange factor 1
External IDs	OMIM: 600303; MGI: 104580; HomoloGene: 50501; GeneCards: RAPGEF1; OMA:RAPGEF1 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	131,740,076 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	29,630,990 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; muscle of thigh; ; apex of heart; ; sural nerve; ; granulocyte; ; nucleus accumbens; ; right lung; ; right frontal lobe; ; right hemisphere of cerebellum; ; caudate nucleus;
	Top expressed in
	otic vesicle; ; saccule; ; muscle of thigh; ; otic placode; ; skeletal muscle tissue; ; ankle; ; knee joint; ; ventricular zone; ; dentate gyrus of hippocampal formation granule cell; ; gastrocnemius muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	SH3 domain binding; protein binding; guanyl-nucleotide exchange factor activity;
Cellular component	cytosol; endosome; early endosome; phagocytic vesicle membrane; perinuclear region of cytoplasm; cytoplasm; protein-containing complex;
Biological process	establishment of endothelial barrier; negative regulation of protein kinase B signaling; cellular response to nerve growth factor stimulus; regulation of cell junction assembly; transmembrane receptor protein tyrosine kinase signaling pathway; small GTPase mediated signal transduction; Rap protein signal transduction; negative regulation of neural precursor cell proliferation; nerve growth factor signaling pathway; nervous system development; negative regulation of Ras protein signal transduction; positive regulation of GTPase activity; blood vessel development; negative regulation of ERK1 and ERK2 cascade; platelet-derived growth factor receptor signaling pathway; negative regulation of canonical Wnt signaling pathway; cellular response to cAMP; signal transduction; positive regulation of neuron projection development; regulation of JNK cascade; positive regulation of ERK1 and ERK2 cascade; positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis; cell-cell adhesion; cytokine-mediated signaling pathway; positive regulation of Ras protein signal transduction; activation of GTPase activity;
	Sources:Amigo / QuickGO
Orthologs
	2889
	107746
	ENSG00000107263
	ENSMUSG00000039844
	Q13905
	n/a
NM_001304275; NM_005312; NM_198679; NM_001377935; NM_001377936;
	NM_001377937; NM_001377938
	NM_001039086; NM_001039087; NM_054050; NM_001362702
NP_001291204; NP_005303; NP_941372; NP_001364864; NP_001364865;
	NP_001364866; NP_001364867
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Rap guanine nucleotide exchange factor 1 is a protein that in humans is encoded by the RAPGEF1 gene.