RAPGEF2

RAPGEF2
Identifiers
Aliases	RAPGEF2, CNrasGEF, NRAPGEP, PDZ-GEF1, PDZGEF1, RA-GEF, RA-GEF-1, Rap-GEP, nRap GEP, Rap guanine nucleotide exchange factor 2, RAGEF
External IDs	OMIM: 609530; MGI: 2659071; HomoloGene: 35477; GeneCards: RAPGEF2; OMA:RAPGEF2 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	159,360,174 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	79,193,824 bp
RNA expression pattern
	Top expressed in
	Brodmann area 23; ; middle temporal gyrus; ; endothelial cell; ; frontal pole; ; postcentral gyrus; ; orbitofrontal cortex; ; tibia; ; Brodmann area 10; ; Brodmann area 46; ; entorhinal cortex;
	Top expressed in
	olfactory tubercle; ; subdivision of hippocampus; ; Region I of hippocampus proper; ; subiculum; ; piriform cortex; ; lateral septal nucleus; ; temporal lobe; ; primary motor cortex; ; Amygdala; ; anterior amygdaloid area;
	More reference expression data
	n/a
Gene ontology
Molecular function	calcium ion binding; protein binding; diacylglycerol binding; signal transducer activity; guanyl-nucleotide exchange factor activity; WW domain binding; phosphatidic acid binding; PDZ domain binding; cAMP binding; cGMP binding; beta-1 adrenergic receptor binding; GTPase activator activity;
Cellular component	cell-cell junction; endocytic vesicle; synapse; integral component of plasma membrane; apical plasma membrane; bicellular tight junction; endosome; cell junction; neuron projection; soma; cytoplasm; cytosol; late endosome; membrane; plasma membrane; perinuclear region of cytoplasm; protein-containing complex; intracellular anatomical structure;
Biological process	positive regulation of ERK1 and ERK2 cascade; brain-derived neurotrophic factor receptor signaling pathway; cellular response to cGMP; ventricular system development; positive regulation of protein binding; forebrain neuron development; regulation of cell junction assembly; protein localization to plasma membrane; positive regulation of neuron projection development; adenylate cyclase-activating adrenergic receptor signaling pathway; nervous system development; neuron migration; neuropeptide signaling pathway; multicellular organism development; G protein-coupled receptor signaling pathway; negative regulation of melanin biosynthetic process; cellular response to nerve growth factor stimulus; cell differentiation; positive regulation of cAMP-mediated signaling; intracellular signal transduction; cellular response to cAMP; nerve growth factor signaling pathway; regulation of cell population proliferation; Rap protein signal transduction; small GTPase mediated signal transduction; negative regulation of cell population proliferation; blood vessel development; positive regulation of dendritic cell apoptotic process; positive regulation of vasculogenesis; microvillus assembly; negative regulation of dendrite morphogenesis; regulation of synaptic plasticity; neuron projection development; establishment of endothelial intestinal barrier; positive regulation of cAMP-dependent protein kinase activity; positive regulation of neuron migration; positive regulation of protein kinase activity; establishment of endothelial barrier; signal transduction; MAPK cascade; positive regulation of GTPase activity; cAMP-mediated signaling;
	Sources:Amigo / QuickGO
Orthologs
	9693
	76089
	ENSG00000109756
	ENSMUSG00000062232
	Q9Y4G8
	Q8CHG7
NM_014247; NM_001351724; NM_001351725; NM_001351726; NM_001351727;
	NM_001351728; NM_001394067
	NM_001099624; NM_001310536
NP_055062; NP_001338653; NP_001338654; NP_001338655; NP_001338656;
	NP_001338657
	NP_001093094; NP_001297465
	Wikidata
View/Edit Human	View/Edit Mouse

Rap guanine nucleotide exchange factor 2 is a protein that in humans is encoded by the RAPGEF2 gene.

RAPGEF2 is a cyclic AMP binding protein.