RAPGEF4

RAPGEF4
Identifiers
Aliases	RAPGEF4, CAMP-GEFII, CGEF2, EPAC, EPAC 2, EPAC2, Nbla00496, Rap guanine nucleotide exchange factor 4
External IDs	OMIM: 606058; MGI: 1917723; HomoloGene: 4451; GeneCards: RAPGEF4; OMA:RAPGEF4 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	173,052,893 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	72,087,818 bp
RNA expression pattern
	Top expressed in
	right frontal lobe; ; Amygdala; ; dorsolateral prefrontal cortex; ; prefrontal cortex; ; Brodmann area 9; ; cingulate gyrus; ; hippocampus proper; ; anterior cingulate cortex; ; nucleus accumbens; ; right adrenal gland;
	Top expressed in
	globus pallidus; ; lateral geniculate nucleus; ; superior frontal gyrus; ; dentate gyrus of hippocampal formation granule cell; ; habenula; ; prefrontal cortex; ; nucleus accumbens; ; anterior amygdaloid area; ; ventral tegmental area; ; lobe of cerebellum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; cAMP binding; protein binding; guanyl-nucleotide exchange factor activity;
Cellular component	cytoplasm; cytosol; membrane; plasma membrane; hippocampal mossy fiber to CA3 synapse;
Biological process	G protein-coupled receptor signaling pathway; intracellular signal transduction; regulation of insulin secretion; small GTPase mediated signal transduction; insulin secretion; regulation of exocytosis; cAMP-mediated signaling; calcium-ion regulated exocytosis; exocytosis; regulation of synaptic vesicle cycle;
	Sources:Amigo / QuickGO
Orthologs
	11069
	56508
	ENSG00000091428
	ENSMUSG00000049044
	Q8WZA2
	Q9EQZ6
	NM_001100397; NM_001282899; NM_001282900; NM_001282901; NM_007023
	NM_001204165; NM_001204166; NM_001204167; NM_019688; NM_001355478
NP_001093867; NP_001269828; NP_001269829; NP_001269830; NP_008954;
	NP_001362793; NP_001362794; NP_001362795; NP_001362796; NP_001362797; NP_001362798; NP_001362799; NP_001362800; NP_001362801; NP_001362802; NP_001362803; NP_001362804; NP_001362805
	NP_001191094; NP_001191095; NP_001191096; NP_062662; NP_001342407
	Wikidata
View/Edit Human	View/Edit Mouse

Rap guanine nucleotide exchange factor (GEF) 4 (RAPGEF4), also known as exchange protein directly activated by cAMP 2 (EPAC2) is a protein that in humans is encoded by the RAPGEF4 gene.

Epac2 is a target of cAMP, a major second messenger in various cells. Epac2 is coded by the RAPGEF4 gene, and is expressed mainly in brain, neuroendocrine, and endocrine tissues. Epac2 functions as a guanine nucleotide exchange factor for the Ras-like small GTPase Rap upon cAMP stimulation. Epac2 is involved in a variety of cAMP-mediated cellular functions in endocrine and neuroendocrine cells and neurons.