RAPGEF5

RAPGEF5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WGY
Identifiers
Aliases	RAPGEF5, GFR, MR-GEF, REPAC, Rap guanine nucleotide exchange factor 5, MRGEF
External IDs	OMIM: 609527; MGI: 2444365; HomoloGene: 56563; GeneCards: RAPGEF5; OMA:RAPGEF5 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	22,357,154 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	117,723,472 bp
RNA expression pattern
	Top expressed in
	inferior ganglion of vagus nerve; ; Pons; ; inferior olivary nucleus; ; corpus callosum; ; superior vestibular nucleus; ; pars reticulata; ; subthalamic nucleus; ; postcentral gyrus; ; external globus pallidus; ; dorsal motor nucleus of vagus nerve;
	Top expressed in
	superior cervical ganglion; ; otolith organ; ; utricle; ; anterior amygdaloid area; ; right lung; ; lateral septal nucleus; ; zygote; ; left lung lobe; ; oocyte; ; secondary oocyte;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	GTP-dependent protein binding; guanyl-nucleotide exchange factor activity;
Cellular component	nucleus; nucleoplasm; nuclear body;
Biological process	small GTPase mediated signal transduction; nervous system development;
	Sources:Amigo / QuickGO
Orthologs
	9771
	217944
	ENSG00000136237
	ENSMUSG00000041992
	Q92565
	Q8C0Q9
	NM_012294; NM_001367600; NM_001367601; NM_001367602; NM_001367603
	NM_175930; NM_001373989
	NP_036426; NP_001354529; NP_001354530; NP_001354531; NP_001354532
	NP_787126; NP_001360918
	Wikidata
View/Edit Human	View/Edit Mouse

Rap guanine nucleotide exchange factor 5 is a protein that in humans is encoded by the RAPGEF5 gene.

Members of the RAS subfamily (see HRAS; MIM 190020) of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF5, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000).[supplied by OMIM]