RAPGEF6

RAPGEF6
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	2D93, 3LNY
Identifiers
Aliases	RAPGEF6, KIA001LB, PDZ-GEF2, PDZGEF2, RA-GEF-2, RAGEF2, Rap guanine nucleotide exchange factor 6
External IDs	OMIM: 610499; MGI: 2384761; HomoloGene: 22968; GeneCards: RAPGEF6; OMA:RAPGEF6 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	131,635,231 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	54,590,111 bp
RNA expression pattern
	Top expressed in
	corpus callosum; ; pancreatic epithelial cell; ; Achilles tendon; ; sperm; ; Brodmann area 23; ; cerebellar vermis; ; superficial temporal artery; ; subthalamic nucleus; ; mucosa of ileum; ; Brodmann area 46;
	Top expressed in
	lymph node; ; mesenteric lymph nodes; ; trigeminal ganglion; ; Paneth cell; ; spermatocyte; ; blood; ; granulocyte; ; spleen; ; facial motor nucleus; ; Rostral migratory stream;
	More reference expression data
	n/a
Gene ontology
Molecular function	phosphatidic acid binding; GTP-dependent protein binding; protein binding; guanyl-nucleotide exchange factor activity;
Cellular component	cytoplasm; cytosol; plasma membrane; endocytic vesicle; apical plasma membrane; membrane; centrosome;
Biological process	regulation of GTPase activity; small GTPase mediated signal transduction; positive regulation of GTPase activity; Ras protein signal transduction; microvillus assembly; protein localization to plasma membrane; establishment of endothelial intestinal barrier; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	51735
	192786
	ENSG00000158987
	ENSMUSG00000037533
	Q8TEU7
	n/a
NM_016340; NM_001164386; NM_001164387; NM_001164388; NM_001164389;
	NM_001164390
	NM_001252494; NM_001252496; NM_001252497; NM_001252498; NM_175258
NP_001157858; NP_001157859; NP_001157860; NP_001157861; NP_001157862;
	NP_057424
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Rap guanine nucleotide exchange factor 6 is a protein that in humans is encoded by the RAPGEF6 gene.