RARRES1

RARRES1
Identifiers
Aliases	RARRES1, LXNL, TIG1, PERG-1, retinoic acid receptor responder 1
External IDs	OMIM: 605090; MGI: 1924461; HomoloGene: 2166; GeneCards: RARRES1; OMA:RARRES1 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	158,732,489 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	67,422,856 bp
RNA expression pattern
	Top expressed in
	pericardium; ; palpebral conjunctiva; ; olfactory zone of nasal mucosa; ; left uterine tube; ; germinal epithelium; ; nasal epithelium; ; gastric mucosa; ; urethra; ; parietal pleura; ; tail of epididymis;
	Top expressed in
	lip; ; skin of external ear; ; skin of abdomen; ; lumbar spinal ganglion; ; left lobe of liver; ; skin of back; ; seminal vesicula; ; embryo; ; spermatocyte; ; esophagus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	metalloendopeptidase inhibitor activity;
Cellular component	integral component of membrane; membrane; extracellular exosome; extracellular space;
Biological process	negative regulation of cell population proliferation; negative regulation of endopeptidase activity;
	Sources:Amigo / QuickGO
Orthologs
	5918
	109222
	ENSG00000118849
	ENSMUSG00000049404
	P49788
	n/a
	NM_002888; NM_206963
	NM_001164763
	NP_002879; NP_996846
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Retinoic acid receptor responder protein 1 is a protein that in humans is encoded by the RARRES1 gene.

This gene was identified as a retinoid acid (RA) receptor-responsive gene. It encodes a type 1 membrane protein. The expression of this gene is upregulated by tazarotene as well as by retinoic acid receptors. The expression of this gene is found to be downregulated in prostate cancer, which is caused by the methylation of its promoter and CpG island. Alternatively spliced transcript variant encoding distinct isoforms have been observed.