RASD2

RASD2
Identifiers
Aliases	RASD2, MGC:4834, Rhes, TEM2, RASD family member 2
External IDs	OMIM: 612842; MGI: 1922391; HomoloGene: 8628; GeneCards: RASD2; OMA:RASD2 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	35,553,999 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	75,950,741 bp
RNA expression pattern
	Top expressed in
	putamen; ; caudate nucleus; ; nucleus accumbens; ; right frontal lobe; ; muscle layer of sigmoid colon; ; apex of heart; ; prefrontal cortex; ; Brodmann area 9; ; cingulate gyrus; ; anterior cingulate cortex;
	Top expressed in
	superior frontal gyrus; ; dorsal striatum; ; nucleus accumbens; ; visual cortex; ; primary visual cortex; ; muscle of thigh; ; nucleus of stria terminalis; ; dentate gyrus of hippocampal formation granule cell; ; olfactory tubercle; ; substantia nigra;
	More reference expression data
	n/a
Gene ontology
Molecular function	G-protein beta-subunit binding; nucleotide binding; GTP binding; ubiquitin conjugating enzyme binding; phosphatidylinositol 3-kinase binding; GTPase activity;
Cellular component	plasma membrane; membrane;
Biological process	negative regulation of protein ubiquitination; regulation of cAMP-mediated signaling; positive regulation of protein kinase B signaling; synaptic transmission, dopaminergic; positive regulation of protein sumoylation; locomotory behavior; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	23551
	75141
	ENSG00000100302
	ENSMUSG00000034472
	Q96D21
	P63032
	NM_014310; NM_001366725; NM_001376515; NM_001376516
	NM_029182
	NP_055125; NP_001353654; NP_001363444; NP_001363445
	NP_083458
	Wikidata
View/Edit Human	View/Edit Mouse

GTP-binding protein Rhes is a protein that in humans is encoded by the RASD2 gene.

This gene encodes a Ras-related protein that is produced largely in the striatum. The product of this gene binds to GTP and possesses intrinsic GTPase activity. The gene belongs to the Ras superfamily of small GTPases. The exact function of this gene is unknown, but most striatum-specific mRNAs characterized to date encode components of signal transduction cascades.