RBBP8

RBBP8
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2L4Z, 4D2H
Identifiers
Aliases	RBBP8, COM1, CTIP, JWDS, RIM, SAE2, SCKL2, retinoblastoma binding protein 8, RB binding protein 8, endonuclease
External IDs	OMIM: 604124; MGI: 2442995; HomoloGene: 28546; GeneCards: RBBP8; OMA:RBBP8 - orthologs
Gene location (Human)
Chr.	Chromosome 18 (human)
End	23,026,488 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	11,878,278 bp
RNA expression pattern
	Top expressed in
	Epithelium of choroid plexus; ; gonad; ; testicle; ; kidney tubule; ; caput epididymis; ; epithelium of lactiferous gland; ; skin of hip; ; lactiferous duct; ; ventricular zone; ; islet of Langerhans;
	Top expressed in
	genital tubercle; ; tail of embryo; ; vestibular sensory epithelium; ; zygote; ; urothelium; ; medullary collecting duct; ; primitive streak; ; spermatocyte; ; secondary oocyte; ; transitional epithelium of urinary bladder;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nuclease activity; hydrolase activity; endonuclease activity; transcription corepressor activity; damaged DNA binding; DNA binding; protein binding; single-stranded DNA endodeoxyribonuclease activity; identical protein binding; Y-form DNA binding; double-strand/single-strand DNA junction binding; double-stranded DNA binding; single-stranded DNA binding; flap-structured DNA binding;
Cellular component	transcription repressor complex; chromosome; nucleus; nucleoplasm; intracellular membrane-bounded organelle; site of double-strand break;
Biological process	cell cycle; DNA repair; nucleotide-excision repair; cell division; nucleic acid phosphodiester bond hydrolysis; response to estradiol; meiosis; regulation of transcription by RNA polymerase II; cellular response to DNA damage stimulus; blastocyst hatching; DNA double-strand break processing; DNA replication; DNA double-strand break processing involved in repair via single-strand annealing; negative regulation of transcription by RNA polymerase II; double-strand break repair via homologous recombination; negative regulation of G0 to G1 transition; negative regulation of nucleic acid-templated transcription; G1/S transition of mitotic cell cycle; regulation of signal transduction by p53 class mediator;
	Sources:Amigo / QuickGO
Orthologs
	5932
	225182
	ENSG00000101773
	ENSMUSG00000041238
	Q99708
	Q80YR6
	NM_002894; NM_203291; NM_203292
	NM_001081223; NM_001252495; NM_175458
	NP_002885; NP_976036; NP_976037; NP_002885.1; NP_976036.1
	NP_001074692; NP_001239424
	Wikidata
View/Edit Human	View/Edit Mouse

Retinoblastoma-binding protein 8 is a protein that in humans is encoded by the RBBP8 gene.