Retinoblastoma-like protein 2

RBL2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4XI9, 5C1D
Identifiers
Aliases	RBL2, P130, Rb2, retinoblastoma-like 2, RB transcriptional corepressor like 2, BRUWAG
External IDs	OMIM: 180203; MGI: 105085; HomoloGene: 4098; GeneCards: RBL2; OMA:RBL2 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	53,491,648 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	91,850,472 bp
RNA expression pattern
	Top expressed in
	germinal epithelium; ; superficial temporal artery; ; epithelium of nasopharynx; ; Achilles tendon; ; lymph node; ; cardia; ; tonsil; ; body of pancreas; ; pylorus; ; mucosa of paranasal sinus;
	Top expressed in
	parotid gland; ; muscle of thigh; ; spermatid; ; saccule; ; medial head of gastrocnemius muscle; ; submandibular gland; ; stroma of bone marrow; ; temporal muscle; ; triceps brachii muscle; ; thymus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; protein binding; promoter-specific chromatin binding; DNA-binding transcription repressor activity, RNA polymerase II-specific;
Cellular component	nucleolus; extracellular exosome; nucleus; transcription regulator complex; nucleoplasm; cytosol; chromatin;
Biological process	regulation of transcription by RNA polymerase II; regulation of cell cycle; cell cycle; regulation of transcription, DNA-templated; transcription, DNA-templated; regulation of lipid kinase activity; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; negative regulation of gene expression; negative regulation of transcription by RNA polymerase II; chromatin organization; regulation of mitotic cell cycle; cell differentiation; regulation of cell division; negative regulation of G1/S transition of mitotic cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	5934
	19651
	ENSG00000103479
	ENSMUSG00000031666
	Q08999
	Q64700
	NM_005611; NM_001323608; NM_001323609; NM_001323610; NM_001323611
	NM_001282000; NM_001282001; NM_011250
	NP_001310537; NP_001310538; NP_001310539; NP_001310540; NP_005602
	NP_001268929; NP_001268930; NP_035380
	Wikidata
View/Edit Human	View/Edit Mouse

Retinoblastoma-like protein 2 is a protein that in humans is encoded by the RBL2 gene. RBL2 is one of three retinoblastoma proteins encoded in the human genome (along with Rb and RBL1).