RBM10

RBM10
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2LXI, 2M2B, 2MXV, 2MXW
Identifiers
Aliases	RBM10, DXS8237E, GPATC9, GPATCH9, S1-1, TARPS, ZRANB5, RNA binding motif protein 10
External IDs	OMIM: 300080; MGI: 2384310; HomoloGene: 31330; GeneCards: RBM10; OMA:RBM10 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	47,186,813 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	20,517,140 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; ventricular zone; ; ganglionic eminence; ; granulocyte; ; left ovary; ; tendon of biceps brachii; ; right ovary; ; pituitary gland; ; anterior pituitary; ; mucosa of transverse colon;
	Top expressed in
	Rostral migratory stream; ; endocardial cushion; ; renal corpuscle; ; medullary collecting duct; ; ureter; ; Paneth cell; ; primitive streak; ; trigeminal ganglion; ; fossa; ; condyle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein-containing complex binding; protein binding; metal ion binding; identical protein binding; nucleic acid binding; RNA binding; miRNA binding;
Cellular component	nucleus; nuclear speck; protein-containing complex;
Biological process	regulation of apoptotic process; mRNA processing; regulation of alternative mRNA splicing, via spliceosome; RNA splicing; negative regulation of transcription by RNA polymerase II; biological process; negative regulation of cell population proliferation; regulation of smooth muscle cell apoptotic process; positive regulation of smooth muscle cell apoptotic process; negative regulation of mRNA splicing, via spliceosome; 3'-UTR-mediated mRNA stabilization;
	Sources:Amigo / QuickGO
Orthologs
	8241
	236732
	ENSG00000182872
	ENSMUSG00000031060
	P98175; Q7Z3D7
	Q99KG3
	NM_001204466; NM_001204467; NM_001204468; NM_005676; NM_152856
NM_001167775; NM_001167776; NM_145627; NM_001358903; NM_001358904;
	NM_001358905
NP_001191395; NP_001191396; NP_001191397; NP_005667; NP_690595;
	NP_001191397.1
NP_001161247; NP_001161248; NP_663602; NP_001345832; NP_001345833;
	NP_001345834
	Wikidata
View/Edit Human	View/Edit Mouse

RNA-binding motif 10 is a protein that is encoded by the RBM10 gene. This gene maps on the X chromosome at Xp11.23 in humans. RBM10 is a regulator of alternative splicing. Alternative splicing is a process associated with gene expression to produce multiple protein isoforms from a single gene, thereby creating functional diversity and cellular complexity. RBM10 influences the expression of many genes, participating in various cellular processes and pathways such as cell proliferation and apoptosis. Its mutations are associated with various human diseases such as TARP syndrome, an X-linked congenital disorder in males resulting in pre‐ or postnatal lethality, and various cancers in adults.